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IL33 — IL4
Text-mined interactions from Literome
De Caterina et al., Am J Clin Nutr 2000
(Arteriosclerosis) :
Consumption of the n-3 fatty acid docosahexaenoic acid ( DHA ; 22 : 6n-3 ) reduced endothelial expression of vascular cell adhesion molecule 1 ( VCAM-1 ), E-selectin, intercellular adhesion molecule 1 ( ICAM-1 ),
interleukin 6 (IL-6), and IL-8 in
response to IL-1,
IL-4 , tumor necrosis factor, or bacterial endotoxin, with a half-maximal inhibitory concentration ( IC ( 50 ) ) of 1-25 micromol, ie, in the range of nutritionally achievable plasma concentrations
Trindade et al., J Orthop Res 1999
:
Interleukin-4 inhibits granulocyte-macrophage colony stimulating factor,
interleukin-6 , and tumor necrosis factor-alpha expression by human monocytes in response to polymethylmethacrylate particle challenge in vitro ...
Interleukin-4 inhibited the expression of granulocyte-macrophage colony stimulating factor,
interleukin-6 , and tumor necrosis factor-alpha at 48 hours in a dose dependent manner
Roy et al., Surgery 2000
:
Interleukin-4 regulates macrophage
interleukin-12 protein synthesis through a c-fos mediated mechanism
Bonder et al., Cytokine 2002
:
While
IL-4 can
suppress LPS induced
interleukin beta ( IL-beta ) and tumour necrosis factor alpha (TNF-alpha) production by monocytes, IL-4 can suppress LPS induced IL-1 beta, but not TNFalpha production by the more differentiated cells
Rollier et al., J Virol 2004
(Hepatitis C, Chronic) :
Immunization induced antibodies, peptide-specific gamma interferon ( IFN-gamma ), protein-specific lymphoproliferative responses, IFN-gamma,
interleukin-2 (IL-2), and
IL-4 T-helper
responses in both vaccinees
Raes et al., J Leukoc Biol 2005
(Asthma...) :
In addition, we demonstrate that in vitro,
interleukin-4 (IL-4) and IL-13 up-regulate mMGL1 and mMGL2 expression and that in vivo, induction of mMGL1 and mMGL2 is
dependent on
IL-4 receptor signaling
Melk et al., Transplantation 2004
(Growth Disorders...) :
During rhGH therapy in children with transplants,
interleukin (IL)-2 production increased threefold at 4 weeks, and
IL-4 and IL-13
increased by 70 % at 12 weeks
Schmitz et al., Immunity 2005
:
In vivo,
IL-33 induces the expression of
IL-4 , IL-5, and IL-13 and leads to severe pathological changes in mucosal organs
Bouchelouche et al., J Urol 2006
:
Interleukin-4 and 13
induce the expression and release of monocyte chemoattractant protein 1,
interleukin-6 and stem cell factor from human detrusor smooth muscle cells : synergy with interleukin-1beta and tumor necrosis factor-alpha
Humphreys et al., J Immunol 2008
(Intestinal Diseases, Parasitic...) :
IL-33 prevents an inappropriate parasite-specific Th1 polarized response and
induces IL-4 , IL-9, and IL-13
Miller et al., J Exp Med 2008
(Atherosclerosis) :
IL-33 also markedly
increased levels of
IL-4 , -5, and -13, but decreased levels of IFNgamma in serum and lymph node cells
Kondo et al., Int Immunol 2008
(Hyperplasia...) :
Basophils, comprising IL-18Ralpha ( + ) cells ( 14.2 % ) and IL-33Ralpha ( + ) cells ( 34.6 % ), and mast cells, comprising IL-18Ralpha ( + ) cells ( 2.0 % ) and IL-33Ralpha ( + ) cells ( 95.6 % ), produce
IL-4 , IL-6, IL-13, granulocyte macrophage colony stimulating factor ( GM-CSF ) and chemokines ( RANTES, MIP-1alpha, MIP-1beta and MCP-1 ), upon
stimulation with IL-18 and/or
IL-33 in the presence of IL-3
Suzukawa et al., J Immunol 2008
:
Expressions of
IL-4 and IL-13 mRNA were also
up-regulated by
IL-33 , and there was also enhanced secretion of IL-4 protein
Bourgeois et al., Eur J Immunol 2009
:
Conversely to the expected pro-Th2 effect,
IL-33 induced a preferential increase in IFN-gamma rather than
IL-4 production upon TCR engagement that depended on endogenous IL-12
Castellani et al., J Biol Regul Homeost Agents 2009
(Asthma...) :
IL-33 is also
involved in the production of IL-5,
IL-4 and IL-13 and several chemokines
Kroeger et al., J Leukoc Biol 2009
:
Using mouse bone marrow derived cultured basophils, we found that
IL-4 and IL-13 are produced in
response to IL-18 or
IL-33 stimulation
Guo et al., Proc Natl Acad Sci U S A 2009
:
Th2 cells that have upregulated T1ST2 produce IL-13, but not
IL-4 , in
response to
IL-33 plus a STAT5 activator in an antigen independent, NF-kappaB dependent, cyclosporin A ( CsA ) -resistant manner
Yin et al., Transplantation 2010
:
In addition,
IL-33 significantly
enhanced the gene expression of Th2-type cytokines
IL-4 and IL-5 but suppressed the Th1-type cytokine IFN-gamma mRNA levels in both allograft and recipient spleen
Matsuba-Kitamura et al., Int Immunol 2010
(Conjunctivitis, Allergic...) :
Eosinophils, stimulated with IL-5 and/or GM-CSF, are responsive to
IL-33 , which
induces production of
IL-4 and chemokines
Saleh et al., Endocrinology 2011
:
In bone marrow cultures,
IL-33 induced mRNA expression of granulocyte macrophage colony stimulating factor,
IL-4 , IL-13, and IL-10 ; osteoclast inhibitory actions of IL-33 were rescued only by combined antibody ablation of these factors
Xing et al., Chin Med J (Engl) 2011
(Alzheimer Disease) :
Ex vivo cultured splenocytes isolated from mice immunized with p ( Aß ( 3-10 ) ) ( 10 ) -CpG exhibited high
interleukin-4 response and low
interleukin-? ( IFN-? )
response
Uchiyama et al., Journal of cardiothoracic surgery 2012
:
Proliferation of splenocytes,
interleukin (IL)-2 and interferon ( IFN ) -? production was suppressed in opera exposed mice, and production of
IL-4 and IL-10 from opera exposed transplant recipients
increased compared to that from splenocytes of untreated recipients
Luzina et al., J Immunol 2012
(Carcinoma, Non-Small-Cell Lung...) :
Both isoforms caused pulmonary infiltration of lymphocytes and neutrophils, whereas mm
IL-33 also
caused pulmonary eosinophilia and goblet cell hyperplasia and increased expression of
IL-4 , IL-5, IL-13, IL-17, MCP-1, and KC
Komai-Koma et al., Allergy 2012
(Anaphylaxis) :
IL-33 induced
IL-4 production was mainly from innate cells including mast cells and eosinophils
Sesti-Costa et al., J Immunol 2013
(Coxsackievirus Infections...) :
Furthermore,
IL-33 triggers the production of
IL-4 from mast cells, which results in enhanced differentiation of M2 macrophages and regulatory T cells, leading to the attenuation of inflammatory pancreatitis
Weiss et al., Eur J Immunol 1989
:
Human T cells and
interleukin 4 inhibit the release of
interleukin 1 induced by lipopolysaccharide in serum-free cultures of autologous monocytes
Hurme et al., Biochem Biophys Res Commun 1988
:
Interleukin-4 inhibits
interleukin-1 synthesis by a posttranscriptional mechanism ...
Interleukin-4 had a clear dose dependent suppressive effect on the
interleukin-1 synthesis
Benveniste et al., Proc Natl Acad Sci U S A 1996
(Acute Disease...) :
Comparative
interleukin ( IL-2 ) /interferon IFN-gamma and
IL-4/IL-10 responses during acute infection of macaques inoculated with attenuated nef truncated or pathogenic SICmac251 virus
Salvucci et al., Eur J Immunol 1996
:
Differential
regulation of
interleukin-12- and interleukin-15 induced natural killer cell activation by
interleukin-4
Gollob et al., Eur J Immunol 1997
:
Interferon-gamma and
interleukin-4 regulate T cell
interleukin-12 responsiveness through the differential modulation of high-affinity interleukin-12 receptor expression