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MYLIP — SOX2

Text-mined interactions from Literome

Otsubo et al., PloS one 2011 (Cell Transformation, Neoplastic...) : Gain- and loss-of function experiments and luciferase assays revealed that miR-126 inhibited SOX2 expression by targeting two binding sites in the 3'-untranslated region ( 3'-UTR ) of SOX2 mRNA in multiple cell lines
Jeon et al., Cancer Res 2011 (Glioma) : ID4 imparts chemoresistance and cancer stemness to glioma cells by derepressing miR-9* mediated suppression of SOX2 ... Together, our results reveal a novel regulatory mechanism by which ID4-driven suppression of miR-9* induces SOX2 , which imparts stemness potential and chemoresistance to glioma cells and GSCs
Yang et al., Biomaterials 2012 (Cell Transformation, Neoplastic...) : We demonstrated that miR145 negatively regulates GBM tumorigenesis by targeting Oct4 and Sox2 in GBM-CD133 ( + )
Das et al., Oncogene 2013 (Neuroblastoma) : Although SOX2 contributes to the maintenance of stem cells in an undifferentiated state, we demonstrate that miR-340 mediated downregulation of SOX2 is not required for ATRA induced differentiation to occur
Campayo et al., Eur Respir J 2013 : miR-145 regulates SOX2 and OCT4 translation and p53 regulates miR-145 expression
Bourguignon et al., J Biol Chem 2012 (Carcinoma, Squamous Cell...) : Hyaluronan-CD44v3 interaction with Oct4-Sox2-Nanog promotes miR-302 expression leading to self-renewal, clonal formation, and cisplatin resistance in cancer stem cells from head and neck squamous cell carcinoma ... Further analysis reveals that microRNA-302 (miR-302) is controlled by an upstream promoter containing Oct4-Sox2-Nanog binding sites, whereas chromatin immunoprecipitation ( ChIP ) assays demonstrate that stimulation of miR-302 expression by HA-CD44 is Oct4-Sox2-Nanog dependent in HNSCC-specific CSCs
Guo et al., Cell Res 2013 (Teratoma) : Here, we report that Sox2 directly regulates endogenous microRNA-29b (miR-29b) expression during iPSC generation and that miR-29b expression is required for OSKM- and OSK mediated reprogramming
Adammek et al., Fertil Steril 2013 (Endometriosis) : In all cells investigated, miR-145 overexpression inhibited cell proliferation and induced down-regulation of FASCIN-1, SOX2 , and MSI2