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TAT — TP53

Text-mined interactions from Literome

Clark et al., J Virol 2000 : An interplay between Tat and p53 has previously been reported, where Tat inhibited the transcription of the p53 gene, which may aid in the development of AIDS related malignancies, and p53 expression inhibited HIV-1 long terminal repeat transcription
Harrod et al., J Biol Chem 2003 (Neuroblastoma) : Human immunodeficiency virus type-1 Tat/co-activator acetyltransferase interactions inhibit p53Lys-320 acetylation and p53-responsive transcription
Snyder et al., Cancer Res 2005 (Neoplasms) : To target tumor cells that overexpress the CXCR4 receptor, we linked the CXCR4 DV3 ligand to two transducible anticancer peptides : a p53 activating peptide ( DV3-TATp53C ' ) and a cyclin dependent kinase 2 antagonist peptide ( DV3-TAT-RxL )
Michod et al., Mol Cancer Res 2007 (MAP Kinase Signaling System...) : TAT-RasGAP317-326 requires p53 and PUMA to sensitize tumor cells to genotoxins ... Here, we report that TAT-RasGAP ( 317-326 ) requires p53 , but not the Ras effectors Akt and extracellular signal regulated kinase, to mediate its tumor sensitization abilities ... These results indicate that TAT-RasGAP ( 317-326 ) sensitizes tumor cells by activating signals that intersect with the p53 pathway downstream of, or at the level of, proapoptotic p53 target gene products to increase the activation of the mitochondrial death pathway
Mukerjee et al., Cell cycle (Georgetown, Tex.) 2008 (AIDS Dementia Complex...) : We found that Tat induced p53 and p73 levels in SH-SY5Y cells and that this induction caused retraction of neurites
Lin et al., J Virol 2010 (HIV Infections) : Furthermore, inhibition of p38 mitogen activated protein kinase ( MAPK ) blocked phosphorylation of p53 in the presence of Tat