Gutgesell et al., Biochim Biophys Acta 2009
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Mouse carnitine-acylcarnitine translocase ( CACT ) is transcriptionally regulated by PPARalpha and PPARdelta in liver cells ... Whether carnitine-acylcarnitine translocase ( CACT ), which mediates the import of acylcarnitines into the mitochondrial matrix for subsequent beta-oxidation of fatty acid moieties, is also regulated by PPARalpha in the liver has not yet been investigated ... The upregulation of CACT by PPARalpha and PPARdelta, which are both important for the regulation of fatty acid oxidation in tissues during fasting, may increase the import of acylcarnitine into the mitochondrial matrix during fasting
Tachibana et al., Biochem Biophys Res Commun 2009
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We previously established tetracycline regulated human cell line that can be induced to express PPARalpha and found that PPARalpha induces the SLC25A20 expression ... In this study, we analyzed the promoter region of the human slc25a20 gene and showed that PPARalpha regulates the expression of human SLC25A20 via the peroxisome proliferator responsive element