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NCL — TP53
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
NCL
—
TP53
(direct interaction, far western blotting)
Daniely et al., Mol Cell Biol 2002*
-
IRef Biogrid Interaction:
NCL
—
TP53
(physical association, affinity chromatography technology)
Daniely et al., Mol Cell Biol 2002*
-
IRef Hprd Interaction:
TP53
—
NCL
(in vivo)
Daniely et al., Mol Cell Biol 2002*
-
IRef Hprd Interaction:
TP53
—
NCL
(in vitro)
Daniely et al., Mol Cell Biol 2002*
-
IRef Intact Interaction:
Complex of NCL-APTX-PARP1-TP53-XRCC1
(association, pull down)
Gueven et al., Hum Mol Genet 2004*
-
IRef Intact Interaction:
Complex of 244 proteins
(association, pull down)
Komarova et al., Mol Cell Proteomics 2011
-
IRef Intact Interaction:
NCL
—
TP53
(direct interaction, pull down)
Bhatt et al., FEBS J 2012*
-
IRef Intact Interaction:
NCL
—
TP53
(direct interaction, far western blotting)
Bhatt et al., FEBS J 2012*
-
IRef Ophid Interaction:
NCL
—
TP53
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Takagi et al., Cell 2005
(Cell Transformation, Neoplastic) :
These findings demonstrate the importance of increased translation of p53 in DNA-damage responses and suggest critical
roles for RPL26 and
nucleolin in affecting
p53 induction
Chen et al., J Biol Chem 2012
:
These observations suggest a model in which the base pairings in the p53 UTR interaction regions are critical for both translational
repression and stress induction of
p53 by
NCL and RPL26, respectively, and that disruption of a NCL-NCL homodimer by RPL26 may be the switch between translational repression and activation after stress