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CD4 — EPHB2

Text-mined interactions from Literome

Jorritsma et al., J Immunol 2003 (MAP Kinase Signaling System) : Stimulation of CD4 ( + ) T cells with a high affinity peptide resulted in sustained Erk activation and Th1 differentiation
Feito et al., Eur J Immunol 2003 (MAP Kinase Signaling System) : H4/ICOS mediated activation of JNK, but not ERK or p38, is partially dependent on the expression of CD4 by the cells, whereas H4/ICOS costimulation is partially independent on CD28 expression
Fischer et al., Immunity 2005 : Erk activity is essential for the process of positive selection, and it differentially affects CD4 and CD8 T cell maturation ; yet, diminished expression itself is not sufficient to alter lineage commitment
Ben-David et al., Scand J Immunol 2007 (Disease Models, Animal...) : Moreover, inhibition of ERK1,2 in the dual APL induced regulatory CD4 ( + ) CD25 ( + ) cells, resulted in downregulation of the forkhead box p3 (Foxp3) gene and protein expression levels, as well as in the downregulation of CD4 ( + ) CD25 ( + ) development, suggesting that the active suppression exerted by the dual APL via CD4 ( + ) CD25 ( + ) cells depends on ERK1,2 activity