UCSC Genome Browser Gene Interaction Graph

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Gene interactions and pathways from curated databases and text-mining

◀ Back to MAPK14

MAP3K5 — MAPK14

Pathways - manually collected, often from reviews:

OpenBEL Selventa BEL large corpus: MAPK14 → MAP3K5 (increases, MAP3K5 Activity, MAPK14 Activity) Yuan et al., J Biol Chem 2003 *
Evidence: Modified assertion
WikiPathways Amyotrophic lateral sclerosis (ALS): MAP3K5 → MAPK14 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

IRef Innatedb Interaction: MAP3K5 — MAPK14 (unknown, -) McLaughlin et al., J Immunol 2006 *

Text-mined interactions from Literome

Korchnak et al., Cell Signal 2009 : Mixed lineage kinase 3 (MLK3) is a mitogen activated protein kinase kinase kinase ( MAP3K ) that activates multiple mitogen activated protein kinase ( MAPK ) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF)
Wu et al., Free Radic Biol Med 2010 (Drug-Induced Liver Injury) : These studies show that TNFalpha increases oxidative stress in mice with elevated CYP2E1, with subsequent activation of ASK-1 via a mechanism involving thioredoxin-ASK-1 dissociation, followed by activation of downstream MKK and MAPK