Gaddis et al., Mol Immunol 2009
:
While upregulation of CD86 was independent of the adaptor molecule MyD88, CD40 upregulation and optimal cytokine ( IL-6, TNF-alpha, IL-12p40, IL-10 and IFN-beta ) production required both MyD88 and TRIF molecules
Gandhapudi et al., PloS one 2013
:
Importantly, TRIF alone caused CD86 and CD40 upregulation on splenic DC, but both TRIF and MyD88 were required for CD80 upregulation