Ganoth et al., Nat Cell Biol 2001
:
Human Cks1 , but not other members of the family, reconstitutes ubiquitin ligation of p27 in a completely purified system, binds to Skp2 and greatly increases binding of T187 phosphorylated p27 to Skp2
Kitajima et al., Am J Pathol 2004
(Carcinoma, Squamous Cell...) :
To study the role of Cks1 overexpression in p27 down-regulation, we transfected Cks1 with or without Skp2 into OSCC cells
Halfter et al., Cancer Res 2006
(Glioblastoma) :
Degradation of p27 in late G ( 1 ) and S phase is initiated by the ubiquitin ligase complex SCF-Skp2/Cks1 Huang et al., PloS one 2012
(Endometrial Neoplasms) :
The data implicates that preventing nuclear p27 degradation by blocking Skp2/Cks1 mediated degradation of p27 or increasing Cdh1 to mediate degradation of Skp2-Cks1 are potential strategies for the prevention and treatment of ECA