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EGR1 — PTGS2

Text-mined interactions from Literome

Sayasith et al., J Mol Endocrinol 2006 : Interestingly, overexpression of EGR-1 increased the levels of mRNA for prostaglandin (PG) G/H synthase-2 ( PGHS-2 ), PG E synthase ( PGES ), PG E2 receptor ( EP2 ), LH receptor (LH-R), but not for cytochrome P450-side chain cleavage ( P450scc ), and cytochrome P450 aromatase (P450arom) in granulosa cultures
Park et al., Cancer Lett 2008 (Carcinoma, Hepatocellular...) : Furthermore, HS-1200 treatment markedly induced the Egr-1 expression at an early time point, and the increased expression levels of p53, p21 WAF1/CIP1, p27 KIP1, and COX-2 after treatment with HS-1200 were completely inhibited in HepG2 cells and partially inhibited in Hep3B cells by silencing of Egr-1, respectively
Díaz-Muñoz et al., Cell Signal 2010 : Coordinated up-regulation of cyclooxygenase-2 and microsomal prostaglandin E synthase 1 transcription by nuclear factor kappa B and early growth response-1 in macrophages ... Inhibition of Egr-1 expression reduced substantially LPS mediated induction of COX-2 and mPGES-1 expression, resulting in a decrease in PGE ( 2 ) production