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CDH1 — ID1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Fernandez-Garcia et al., Oncogene 2005
(Carcinoma...) :
Ectopic overexpression of
Id1 was not
sufficient to induce
E-cadherin , which was critical for the morphological changes induced by 1alpha,25 ( OH ) 2D3 in SW480-ADH cells ... Ectopic overexpression of
Id1 was not
sufficient to induce
E-cadherin , which was critical for the morphological changes induced by 1alpha,25 ( OH ) 2D3 in SW480-ADH cells
Li et al., J Am Soc Nephrol 2007
:
Ectopic expression of
Id1 suppressed epithelial
E-cadherin and zonula occludens-1 expression
Wang et al., Oncogene 2008
(Chromosomal Instability) :
On the other hand, overexpression of
Cdh1 leads to
Id-1 protein degradation, suggesting that Id-1 may also act as a substrate of APC ( Cdh1 )
Helbing et al., J Pathol 2013
(Lung Injury) :
BMP2 is up-regulated after epithelial injury and causes epithelial dysfunction and hyperpermeability, mediated by the
Smad1/5-Id1 dependent down-regulation of
E-cadherin