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IL13 — RELA
Text-mined interactions from Literome
Takeda et al., Science 1999
(Limb Deformities, Congenital...) :
In contrast, there was no impairment of
NF-kappaB activation
induced by either
interleukin-1 or tumor necrosis factor-alpha in IKKalpha-deficient embryonic fibroblasts and thymocytes, indicating that IKKalpha is not essential for cytokine induced activation of NF-kappaB
Vig et al., J Biol Chem 1999
:
Modulation of tumor necrosis factor and
interleukin-1 dependent
NF-kappaB activity by mPLK/IRAK
Li et al., J Exp Med 1999
:
Accordingly, IKKbeta-deficient cells are defective in activation of IKK and
NF-kappaB in
response to either tumor necrosis factor alpha or
interleukin 1
Seppänen et al., Oncol Res 1998
(Adenocarcinoma...) :
In the present study, we have investigated the
effects of interferons-alpha (IFN-alpha) and -gamma ( IFN-gamma ),
interleukin-10 (IL-10) and -13 ( IL-13 ), transforming growth factor-beta1 ( TGF-beta1 ), granulocyte-macrophage colony stimulating factor ( GM-CSF ), and tumor necrosis factor-alpha (TNF-alpha) on cell proliferation and induction of transcription factors AP-1 and
NF-kappaB in UM-EC-3 human endometrial adenocarcinoma cells and UT-OC-5 ovarian carcinoma cells in vitro
Greene et al., Biochim Biophys Acta 1999
:
Interleukin-1 receptor associated kinase, IRAK, has been shown to activate
NFkappaB in
response to
interleukin-1
Belt et al., Am J Obstet Gynecol 1999
:
In this study we investigated the possible
role of the nuclear transcription factor
NF-kappaB in
interleukin-1 signaling, leading to the expression of cyclooxygenase 2 and prostaglandin production in human myometrial cell cultures ... Stimulation of human myometrial cells with
interleukin 1
leads to rapid activation of the transcription factor
NF-kappaB , which is functionally linked to the expression of cyclooxygenase 2 messenger ribonucleic acid, protein, and prostaglandin synthesis
Egan et al., J Biol Chem 1999
:
Inhibition of
interleukin-1 stimulated
NF-kappaB RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity ... Inhibition of
interleukin-1 stimulated NF-kappaB
RelA/p65 phosphorylation by mesalamine is accompanied by decreased transcriptional activity
Sun et al., Nature 2000
:
Activation of
NF-kappaB by tumour-necrosis factor alpha and
interleukin-1 was unaffected in the mutant mice
Iber et al., Arch Biochem Biophys 2000
:
Suppression of CYP2C11 gene transcription by
interleukin-1 mediated by
NF-kappaB binding at the transcription start site
Takeuchi et al., Antioxid Redox Signal 2000
:
Thioredoxin inhibits tumor necrosis factor- or
interleukin-1 induced
NF-kappaB activation at a level upstream of NF-kappaB inducing kinase
Van Huffel et al., J Biol Chem 2001
:
NF-kappaB activation
induced by TNF and
interleukin-1 is inhibited by overexpression of ABIN-2
Fichorova et al., J Infect Dis 2001
(HIV Infections...) :
Analysis of molecular and cellular components in cervicovaginal secretions, as well as results from in vitro activation of cervicovaginal epithelial cells and U1/HIV promonocytic cells, showed that multiple N-9 use can promote HIV-1 transmission through
interleukin-1 mediated
NF-kappaB activation, which leads to chemokine induced recruitment of HIV-1 host cells and increased HIV-1 replication in infected cells
Qian et al., J Biol Chem 2001
:
IRAK mediated translocation of TRAF6 and TAB2 in the
interleukin-1 induced activation of
NFkappa B
Bradbury et al., Cancer Res 2001
:
Recently, it also has been demonstrated that nonsteroidal anti-inflammatory agents inhibit tumor necrosis factor and
interleukin-1 induced
NF-kappaB activation and act as radiosensitizing agents
Wright et al., Am J Physiol Heart Circ Physiol 2002
:
However,
interleukin-1beta and phorbol 12-myristate 13-acetate also
activated NF-kappaB but did not evoke TNF-alpha expression, revealing that this factor is not sufficient for cytokine production
Palanki et al., Curr Med Chem 2002
(Autoimmune Diseases) :
In activated T cells, transcription factors such as the activator protein-1 (AP-1) regulate IL-2 production and production of matrix metalloproteinases, the
nuclear factor kappa B (NF-kappa B) is essential for the transcriptional regulation of the proinflammatory cytokines IL-1, IL-6, IL-8 and TNF alpha, and nuclear factor of activated T-cells ( NFAT ) is
required for the transcriptional regulation of IL-2, IL-3, IL-4, IL-5, IL-8,
IL-13 , TNF alpha, and GM-CSF
Friedman et al., J Virol 2002
:
We demonstrate here that the E3 region of Ad inhibits the activation of
NF-kappa B induced by tumor necrosis factor alpha (TNF-alpha) and
interleukin-1
Liacini et al., Matrix Biol 2002
(Osteoarthritis, Hip) :
Inhibition of
interleukin-1 stimulated MAP kinases, activating protein-1 (AP-1) and
nuclear factor kappa B (NF-kappa B) transcription factors down-regulates matrix metalloproteinase gene expression in articular chondrocytes
Ward et al., Mol Cell Biochem 2002
(Acute Disease...) :
IL-10 and
IL-13 attenuate
NF-kappaB activation by interfering with breakdown of IkappaBalpha, while SLPI likewise suppresses NF-kappaB activation, but by interfering with breakdown of IkappaBbeta ... Antibody induced blockade of IL-10,
IL-13 or SLPI
enhances NF-KB activation in lung and exacerbates the lung inflammatory response and injury
Raychaudhuri et al., Clin Immunol 2002
(Hypertension, Pulmonary) :
However, mRNA expression was decreased compared to controls for
NF-kappaB regulated genes, granulocyte macrophage colony stimulating factor,
interleukin-6 , macrophage inflammatory protein-1alpha ( MIP-1alpha ), and vascular endothelial growth factor
Cogswell et al., J Biol Chem 2003
:
Stimulation of cells with inflammatory cytokines such as tumor necrosis factor alpha or
interleukin-1 induces the degradation of I kappa B, the
inhibitor of
NF-kappa B , allowing nuclear accumulation of NF-kappa B and regulation of specific gene expression
Jiang et al., J Biol Chem 2004
:
Without ERK activation,
interleukin-1beta induces only acute and transient
NF-kappaB activation
Takada et al., J Biol Chem 2004
:
PTD-p65-P1 suppressed
NF-kappaB activation
induced by lipopolysaccharide,
interleukin-1 , okadaic acid, phorbol 12-myristate 13-acetate, H ( 2 ) O ( 2 ), and cigarette smoke condensate as well as that induced by TNF
Shishodia et al., J Biol Chem 2004
(Inflammation...) :
Guggulsterone suppressed DNA binding of
NF-kappaB induced by tumor necrosis factor (TNF), phorbol ester, okadaic acid, cigarette smoke condensate, hydrogen peroxide, and
interleukin-1
Kwon et al., Mol Cell Biol 2004
:
Signaling molecule that interacts with mouse pelle-like kinase ( SIMPL ) is a signaling component required for tumor necrosis factor alpha (TNF-alpha) dependent but not
interleukin-1 dependent
NF-kappaB activation
Rodriguez-Galán et al., J Immunol 2005
:
The IL-2-plus-IL-18 or IL-12-plus-IL-18 effect on IFN-gamma and
IL-13 expression is
dependent on Stat4 and
NF-kappaB but independent of Stat6, T-bet, or NFAT
Feng et al., Mol Cell Biol 2005
:
The LIM protein Ajuba influences
interleukin-1 induced
NF-kappaB activation by affecting the assembly and activity of the protein kinase Czeta/p62/TRAF6 signaling complex
Wang et al., Nat Immunol 2006
:
Tumor necrosis factor receptor associated factor 6 ( TRAF6 ) is critical for mediating Toll-like receptor ( TLR )
-interleukin 1 receptor (IL-1R) signaling and subsequent
activation of
NF-kappaB and AP-1, transcriptional activators of innate immunity
LaVallie et al., J Biol Chem 2006
(Osteoarthritis) :
Protein kinase Czeta is up-regulated in osteoarthritic cartilage and is required for
activation of
NF-kappaB by tumor necrosis factor and
interleukin-1 in articular chondrocytes
Komine et al., Mol Immunol 2007
(Periodontitis) :
Con A low-affinity saliva Lf peptides, PR3 treated Lf preparation and two of four synthetic polypeptides induced the production of
interleukin IL-6, monocyte chemoattractant protein-1 and IL-8, and the
activation of
NF-kappaB in human oral epithelial HSC-2 cells
Suzuki et al., Trends Immunol 2006
:
Although each system seems to possess distinct activation mechanisms,
interleukin-1 receptor associated kinase ( IRAK)-4 is
essential for
NF-kappaB activation in Toll-like receptor ( TLR ) and T-cell receptor ( TCR ) signaling pathways
Wullaert et al., J Biol Chem 2007
:
Similar to the other ABINs, ABIN-3 binds to A20 and inhibits
NF-kappaB activation
induced by tumor necrosis factor,
interleukin-1 , and 12-O-tetradecanoylphorbol-13-acetate
Ahn et al., J Biol Chem 2007
:
Besides TNF, gamma-tocotrienol also abolished
NF-kappaB activation
induced by phorbol myristate acetate, okadaic acid, lipopolysaccharide, cigarette smoke,
interleukin-1beta , and epidermal growth factor
Hohmann et al., J Biol Chem 1992
(Leukemia, Promyelocytic, Acute) :
NF-kappa B activation by phorbol 12-myristate 13-acetate ( PMA ) and
interleukin-1 was inhibited by staurosporin
Manna et al., Clin Cancer Res 2007
(Inflammation...) :
We showed by DNA binding assay that
NF-kappaB activation
induced by tumor necrosis factor (TNF), phorbol 12-myristate 13-acetate, lipopolysaccharide, ceramide,
interleukin-1 , and H ( 2 ) O ( 2 ) was suppressed by morin ; the suppression was not cell type specific
Krasnow et al., Cytokine 1991
(Lymphoma, T-Cell) :
Tumor necrosis factor-alpha,
interleukin 1, and phorbol myristate acetate are independent
activators of
NF-kappa B which differentially activate T cells
Shembade et al., J Virol 2007
:
Mouse fibroblasts lacking Ubc13 exhibit impaired Tax activation of NF-kappaB despite normal tumor necrosis factor- and
interleukin-1 mediated
NF-kappaB activation
Dey et al., Cell Death Differ 2008
:
We show in this study that R-Roscovitine can downregulate
nuclear factor-kappa B (NF-kappaB) activation in
response to tumor necrosis factor (TNF)alpha and
interleukin 1
Kim et al., Mol Pharmacol 2008
(Inflammation...) :
BOT-64 attenuates
NF-kappaB regulated expression of inflammatory genes such as inducible nitric-oxide synthase, cyclooxygenase-2, tumor necrosis factor-alpha,
interleukin (IL)-1beta , and IL-6 in LPS activated or expression vector IKKbeta transfected macrophages
Xiao et al., J Biol Chem 2008
:
Pellino 3b negatively regulates
interleukin-1 induced TAK1 dependent
NF kappaB activation
Dasu et al., Diabetes 2008
:
High glucose increased TLR expression, myeloid differentiation factor 88,
interleukin-1 receptor associated kinase-1, and
nuclear factor-kappaB (NF-kappaB) p65 dependent
activation in THP-1 cells
Wijagkanalan et al., Mol Pharmacol 2008
(Pneumonia) :
DPML significantly inhibited tumor necrosis factor alpha,
interleukin-1beta , and cytokine induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and
inhibited NFkappaB and p38 mitogen activated protein kinase activation in the lung
Inagaki et al., J Biol Chem 2008
:
Tumor necrosis factor- and
interleukin-1 induced activation of TAK1 was entirely normal in Tab1-deficient MEFs and could
activate both mitogen activated protein kinases and
NF-kappaB
Goto et al., Cytokine 2009
:
IL-13 induces translocation of
NF-kappaB in cultured human bronchial smooth muscle cells ... In the present study, whether
IL-13 induces an activation of
nuclear factor (NF)-kappaB , inflammatory transcription factor, was investigated in human bronchial smooth muscle cells ( hBSMCs )
Gao et al., Cell Mol Life Sci 2009
:
Transforming growth factor-beta activated kinase 1 ( TAK1 ) is a serine/threonine protein kinase that is critically involved in the
activation of
NF-kappaB by tumor necrosis factor ( TNFalpha ),
interleukin-1beta (IL-1beta) and TLR ligands
de Mejia et al., Peptides 2009
(Inflammation) :
The 5 kDa peptide inhibited most potently pro-inflammatory markers including interleukin-6 production ( IC ( 50 ) =2 microM ),
interleukin-1beta production ( IC ( 50 ) =13 microM ),
nuclear factor-kappa B (NF-kappaB) transactivation ( IC ( 50 ) =21 microM ), cyclooxygenase-2 expression ( IC ( 50 ) =25 microM ), nitric oxide production ( IC ( 50 ) =28 microM ), inducible nitric oxide synthase expression ( IC ( 50 ) =37 microM ), prostaglandin E ( 2 ) production ( IC ( 50 ) =41 microM ), p65 nuclear translocation ( IC ( 50 ) =48 microM ) and p50 nuclear translocation ( IC ( 50 ) =77 microM )
Sheller et al., Exp Lung Res 2009
(Asthma...) :
Accompanying the exaggerated inflammation was an increase in the cytokines granulocyte colony stimulating factor ( G-CSF ), interleukin (IL)-15, and KC. Interestingly, the counter regulatory
interleukin , IL-10, was
suppressed by
NF-kappa B activation
Shinozaki et al., Biochem Biophys Res Commun 2010
(Fibrosis...) :
IL-13 inhibited the transcriptional activity of
NF-kappaB , and the expression of mutant I-kappaB reproduced the suppression of autocrine TGF-beta(1) and promoted PSCs proliferation
Munitz et al., Gastroenterology 2010
(Colitis...) :
In vitro analysis showed increased production of proinflammatory cytokines ( interleukin-6,
interleukin-1beta , and tumor necrosis factor alpha ) and
activation of MAPK and
NF-kappaB in Pirb-/- macrophages following bacterial activation
Schreck et al., EMBO J 1991
:
NAC and other thiol compounds also blocked the
activation of
NF-kappa B by cycloheximide, double stranded RNA, calcium ionophore, TNF-alpha, active phorbol ester,
interleukin-1 , lipopolysaccharide and lectin
Powolny-Budnicka et al., Immunity 2011
(Bacterial Infections) :
RelA and RelB transcription factors in distinct thymocyte populations
control lymphotoxin dependent
interleukin-17 production in ?d T cells
Mahon et al., J Biol Chem 1995
(Lymphoma, T-Cell...) :
The tyrosine kinase inhibitor herbimycin A was found to block
NF-kappa B stimulation in
response to
interleukin-1 and phorbol 12-myristate 13-acetate in EL4.NOB-1 thymoma cells and phorbol 12-myristate 13-acetate in Jurkat T lymphoma cells
Lewis et al., Mol Cell Biol 1994
:
Mutational analysis of the -127/-118 NF-kappa B site indicates that both
NF-kappa B and HMG-I(Y) binding at this site are
essential for
interleukin-1 induction of the promoter
Scheinman et al., Mol Cell Biol 1995
:
In HeLa cells, DEX activation of endogenous GR is sufficient to block tumor necrosis factor alpha or
interleukin 1
activation of
NF-kappa B at the levels of both DNA binding and transcriptional activation
Ng et al., J Biol Chem 1994
:
Although tumor necrosis factor (TNF) and
interleukin-1 ( IL ) induce the expression of the IL-8, TNF stimulated gene 6, and plasminogen activation inhibitor-2 genes and the activation of
NF-kappa B with nearly identical kinetics, the two cytokines differ significantly in the induction of the IL-6 gene in all primary fibroblasts tested
De Valck et al., Biochem Biophys Res Commun 1997
:
However, A20 mutants that no longer associated with 14-3-3 proteins could still fully inhibit
NF-kappaB activation
induced by tumor necrosis factor,
interleukin-1beta or phorbol 12-myristate 13-acetate, thus excluding a crucial role for 14-3-3 interaction in this A20 function
Bowie et al., J Biol Chem 1997
:
Here we have investigated the effect of a range of putative antioxidants on
NF-kappaB activation by
interleukin-1 and tumor necrosis factor as well as the ability of H2O2 to activate NF-kappaB in primary human umbilical vein endothelial cells and the transformed human endothelial cell line ECV304
Lentsch et al., J Clin Invest 1997
:
In this study, we sought to determine whether the protective effects of IL-10 and
IL-13 in IgG immune complex induced lung injury were
mediated by inhibition of
NF-kappa B activation
Chaturvedi et al., J Biol Chem 1997
:
As sanguinarine also inhibited
NF-kappaB activation
induced by
interleukin-1 , phorbol ester, and okadaic acid but not that activated by hydrogen peroxide or ceramide, the pathway leading to NF-kappaB activation is likely different for different inducers
Gri et al., J Biol Chem 1998
(Cell Transformation, Viral) :
Synergistic
regulation of the human
interleukin-12 p40 promoter by
NFkappaB and Ets transcription factors in Epstein-Barr virus transformed B cells and macrophages
Giri et al., J Biol Chem 1998
(Lymphoma, T-Cell...) :
HuT-78 cells were also resistant to
NF-kappaB activation
induced by phorbol ester, H2O2, ceramide, endotoxin, and
interleukin-1
Heitmeier et al., J Biol Chem 1998
:
Double stranded RNA induced inducible nitric-oxide synthase expression and
interleukin-1 release by murine macrophages
requires NF-kappaB activation
Schwager et al., Vet Immunol Immunopathol 1998
(Ascorbic Acid Deficiency...) :
The results suggest that ascorbate levels exert an early effect on immune homeostasis via reactive oxygen intermediates ( ROI ) -dependent expression of interleukin genes, since the transcription factor
NF-kappa B is sensitive to ROI and
regulates the expression of
interleukin genes
Manna et al., J Immunol 1998
:
IL-13 also
inhibited NF-kappa B activation by LPS, okadaic acid, H2O2, and ceramide ... TNF induced
NF-kappa B-dependent gene transcription was also
blocked by
IL-13
Béraud et al., Proc Natl Acad Sci U S A 1999
:
The compound had virtually no effect on tumor necrosis factor- and
interleukin-1 induced
NF-kappaB activities
Lentsch et al., J Immunol 1999
(Acute Disease...) :
In the
presence of
anti-IL-13 , activation of the transcription factor,
NF-kappaB , was significantly increased in lung ... These data suggest that during lung inflammation endogenous
IL-13 regulates
NF-kappaB activation and related cytokine/chemokine generation, all of which determines the intensity of the lung inflammatory response