◀ Back to FGF23
FGF23 — FGF7
Pathways - manually collected, often from reviews:
-
Reactome Reaction:
FGF7
→
FGF23
(reaction)
Carpenter et al., Exp Cell Res 1999, Wong et al., Proc Natl Acad Sci U S A 2002, Lax et al., Mol Cell 2002, Fong et al., J Biol Chem 2003, Agazie et al., Oncogene 2003, Takeda et al., Clin Cancer Res 2007, Ahmed et al., Biochem J 2008, Byron et al., Cancer Res 2008, Schüller et al., Biochem J 2008, Qing et al., J Clin Invest 2009, Turner et al., Nat Rev Cancer 2010, Bai et al., Cancer Res 2010, Dutt et al., PloS one 2011, Wesche et al., Biochem J 2011, Klint et al., J Biol Chem 1995, Wang et al., Mol Cell Biol 1994, Ong et al., Biochem Biophys Res Commun 1996, Kanai et al., J Biol Chem 1997, Kouhara et al., Cell 1997, Ong et al., Biochem Biophys Res Commun 1997, Hadari et al., Mol Cell Biol 1998, Raffioni et al., J Biol Chem 1998
Text-mined interactions from Literome
Shimada et al., American journal of physiology. Renal physiology 2005
:
Taken together,
FGF23 works, at least in part, in a VDR independent manner, and
FGF23 production is also
regulated by multiple mechanisms involving VDR independent pathways
Komi-Kuramochi et al., J Endocrinol 2005
:
In young adult mice ( 8 weeks old ),
FGF7 , FGF10 and FGF22 mRNAs were all strongly expressed in healthy skin, and levels of
FGF7 and 10 but not 22
increased 2- to 3.5-fold over differing time courses after wounding
Torres et al., Kidney Int 2007
:
Klotho can act as a circulating factor or hormone, which binds to a not yet identified high-affinity receptor and inhibits the intracellular insulin/insulin-like growth factor-1 (IGF-1) signaling cascade ; klotho can function as a novel beta-glucuronidase, which deglycosylates steroid beta-glucuronides and the calcium channel transient receptor potential vallinoid-5 ( TRPV5 ) ; as a cofactor essential for the
stimulation of
fibroblast growth factor ( FGF ) receptor by
FGF23
Liu et al., Mol Endocrinol 2009
(Disease Models, Animal) :
Moreover, activation of
Fgf and Wnt signaling
stimulated Fgf23 promoter activity in osteoblasts
Liu et al., Am J Physiol Heart Circ Physiol 2009
(Hypertrophy, Left Ventricular...) :
To assess whether
FGF-23 influences the function and structure of the CVS and whether the effect of FGF-23 on the CVS is
mediated by
FGF receptors directly or indirectly by hypophosphatemia, FGF-23 transgenic mice and their wild-type littermates were fed a normal diet or a high-phosphate diet comprising a normal diet plus 1.25 % phosphate in drinking water from weaning for 5 wk, and the phenotypes of the CVS were compared between FGF-23 transgenic mice and their wild-type littermates on the same diet
Yamamoto et al., J Endocrinol 2010
:
Parathyroid hormone, stanniocalcin 1, prostaglandin E ( 2 ),
FGF2 , and foscarnet did not
increase FGF23 mRNA expression
Isakova et al., Nephrol Dial Transplant 2011
(Kidney Failure, Chronic) :
Despite the significant reductions in 24-h urinary phosphate excretion, no group demonstrated a significant reduction in
FGF23 levels
; FGF23 levels actually
increased significantly in the 1500-mg diet plus placebo group, suggesting dietary phosphorus loading
Bergwitz et al., Adv Exp Med Biol 2012
(Abnormalities, Multiple...) :
FGF23 acts through
FGF-receptors and the coreceptor Klotho to reduce 1,25 ( OH ) ( 2 ) D synthesis in the kidney and probably the synthesis of parathyroid hormone (PTH) by the parathyroid glands
Razzaque et al., Adv Exp Med Biol 2012
(Kidney Diseases) :
Vitamin D can
induce the expression of both
FGF23 and klotho while,
FGF23 can suppress renal expression of 1a ( OH ) ase to reduce 1,25 ( OH ) ( 2 ) D activity
Bhattacharyya et al., Trends Endocrinol Metab 2012
(Iron Metabolism Disorders...) :
In physiologic states,
FGF23 signaling is
mediated by an
FGF receptor and the coreceptor, Klotho