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GSK3B — PI3
Text-mined interactions from Literome
Crowder et al., J Biol Chem 2000
:
Stimulation with NGF resulted in
PI 3-kinase dependent phosphorylation of
GSK-3 beta and inhibition of its protein kinase activity, indicating that GSK-3 beta is targeted by PI 3-kinase/Akt in these neurons
Hetman et al., J Biol Chem 2002
:
Interestingly,
PI3K ( but not ERK1/2 )
induced the inhibitory phosphorylation of
GSK3beta at Ser-9
Kanzaki et al., J Cell Biol 2004
:
Furthermore, insulin induced
GSK-3beta phosphorylation was
mediated by both
PI 3-kinase-PKB and the TC10-Par6-atypical PKC signaling pathways
Kuemmerle et al., Am J Physiol Gastrointest Liver Physiol 2005
:
IGF-I dependent
GSK-3 beta phosphorylation and the resulting GSK-3 beta inactivation were
mediated by activation of a
PI3-kinase dependent, phosphoinositide dependent kinase-1 ( PDK-1 ) -dependent, and Akt dependent mechanism
Kirshenboim et al., J Mol Neurosci 2004
:
Lithium mediated phosphorylation of
glycogen synthase kinase-3beta involves
PI3 kinase dependent activation of protein kinase C-alpha
Beurel et al., Int J Oncol 2005
(Carcinoma, Hepatocellular) :
Therefore,
PI3K mediated
GSK-3beta inhibition could be a mechanism by which cancer cells escape from chemotherapy induced apoptosis
Abbosh et al., Thyroid 2005
(Thyroid Neoplasms) :
Activation of AKT by
phosphatidylinositide-3 kinase (PI3K) , a RAS effector,
results in
GSK3beta phosphorylation and deactivation and subsequent beta-catenin upregulation in thyroid cancer
Almeida et al., J Biol Chem 2005
:
Wnt3a induced phosphorylation of
GSK-3beta and downstream activation of beta-catenin mediated transcription
required ERK,
PI3K , and Akt signaling
Fothergill et al., Virology 2006
(MAP Kinase Signaling System) :
VLP induced
PI3-kinase activity
resulted in efficient downstream signaling to Akt and consequent phosphorylation of FKHR and
GSK3beta
Peng et al., Zhonghua Xin Xue Guan Bing Za Zhi 2006
(Myocardial Reperfusion Injury) :
Phosphatidylinositol 3-kinase (PI3K) inhibitor wortmannin
prevented the increase of phospho-protein kinase B/Akt ( Ser473 ) and
phospho-glycogen synthase kinase-3beta ( Ser9 ) induced by ischemic postconditioning, but only partly abolished the cardioprotection of ischemic postconditioning
Gowan et al., Assay Drug Dev Technol 2007
(Neoplasms, Experimental) :
In this paper, optimization of the Meso Scale Discovery (MSD) ( Gaithersburg, MD ) platform to quantify changes in phospho-AKT and
phospho-glycogen synthase kinase-3beta in
response to a
PI3-kinase inhibitor, LY294002, is described, initially in vitro and then within xenografted solid tumors
Nishihara et al., J Mol Cell Cardiol 2007
(Disease Models, Animal...) :
A PKC inhibitor and a
PI3 kinase inhibitor
suppressed the IPC+EPO induced increase in the level of
phospho-GSK-3beta-ANT complex
Duarte et al., Biochim Biophys Acta 2008
:
Since
phosphatidylinositol 3-kinase (PI-3K)/Akt mediated inhibition of
GSK-3beta may stimulate protein synthesis and decrease apoptosis, we analysed mRNA and protein expression of `` candidate '' proteins involved in antioxidant defense, glucose metabolism and apoptosis
Nair et al., J Biol Chem 2008
:
In contrast, inhibition of
PI-3K blocked the phosphorylation of Akt and
GSK-3beta ( activation ) and prevented the protection mediated by ropinirole
Kim et al., Cancer Lett 2008
(Breast Neoplasms...) :
In addition, the basal activities of Akt and
GSK-3beta were deregulated in MCF-7/ADR cells, and either the activation of
PI3-kinase or the inhibition of GSK-3
restored the diminished transcription of VEGF
Mariappan et al., J Biol Chem 2008
(Diabetes Mellitus, Type 2...) :
Incubation with selective kinase inhibitors showed that high glucose- and high insulin induced laminin beta1 synthesis and phosphorylation of
GSK3beta were
dependent on
PI 3-kinase , Erk, and mTOR
Lee et al., Life Sci 2009
:
We found that CAPE induces rapid and transient phosphorylation of
glycogen synthase kinase (GSK)-3beta in a
phosphoinositide 3-kinase (PI3K) dependent manner