Zheng et al., FASEB J 2010
(Muscular Atrophy) :
The PI3K/Akt pathway inhibits the FOXO mediated transcription of the muscle-specific E3 ligase atrogin-1/MAFbx (AT-1) , whereas the MEK/ERK pathway increases Sp1 activity and ubiquitin ( UbC ) expression
Reed et al., FASEB J 2012
(Cachexia...) :
Expression of DN FoxO inhibited the increased mRNA levels of atrogin-1 , MuRF1, cathepsin L, and/or Bnip3 and inhibited muscle fiber atrophy during cancer cachexia and sepsis
Murray et al., FASEB J 2013
:
ROS activation of FoxO and NF-?B and their downstream targets, atrogin-1 and MuRF1, was observed in M-ERR? ( -/- ) myocytes