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NOD2 — RIPK2

Pathways - manually collected, often from reviews:

• KEGG NOD-like receptor signaling pathway: NOD2 → RIPK2 (protein-protein, activation)
• KEGG Shigellosis: NOD1/NOD2 → RIPK2 (protein-protein, activation)
• KEGG Tuberculosis: NOD2 → RIPK2 (protein-protein, activation)
• NCI Pathway Database Canonical NF-kappaB pathway: RIP2/NOD2 complex (RIPK2-NOD2) → NEMO (IKBKG) (modification, activates) Abbott et al., Curr Biol 2004*
  Evidence: mutant phenotype, assay
• Reactome Reaction: NOD2 → RIPK2 (indirect_complex) Bertin et al., J Biol Chem 1999*, Inohara et al., J Biol Chem 1999*, Ogura et al., J Biol Chem 2001*
• Reactome Reaction: NOD2 → RIPK2 (reaction) Bertin et al., J Biol Chem 1999*, Inohara et al., J Biol Chem 1999*, Ogura et al., J Biol Chem 2001*
• WikiPathways Nucleotide-binding Oligomerization Domain (NOD) pathway: NOD2 → RIPK2 (unknown)

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Bind Interaction: NOD2 — RIPK2 Ogura et al., J Biol Chem 2001*
• IRef Bind_translation Interaction: NOD2 — RIPK2 (coimmunoprecipitation) Ogura et al., J Biol Chem 2001*
• IRef Biogrid Interaction: NOD2 — RIPK2 (physical association, affinity chromatography technology) Damgaard et al., Mol Cell 2012
• IRef Biogrid Interaction: NOD2 — RIPK2 (physical association, affinity chromatography technology) Marinis et al., J Biol Chem 2011*
• IRef Biogrid Interaction: NOD2 — RIPK2 (physical association, affinity chromatography technology) Ogura et al., J Biol Chem 2001*
• IRef Biogrid Interaction: NOD2 — RIPK2 (physical association, affinity chromatography technology) Abbott et al., Curr Biol 2004*
• IRef Biogrid Interaction: NOD2 — RIPK2 (physical association, affinity chromatography technology) Tao et al., Curr Biol 2009*
• IRef Biogrid Interaction: NOD2 — RIPK2 (physical association, affinity chromatography technology) Tigno-Aranjuez et al., Genes Dev 2010*
• IRef Dip Interaction: Complex of NOD2-RIPK2-XIAP (pull down) Krieg et al., Proc Natl Acad Sci U S A 2009*
• IRef Hprd Interaction: NOD2 — RIPK2 (in vivo) Ogura et al., J Biol Chem 2001*
• IRef Intact Interaction: NOD2 — RIPK2 (physical association, coimmunoprecipitation) Ogura et al., J Biol Chem 2001*
• IRef Ophid Interaction: NOD2 — RIPK2 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Hall et al., Eur J Immunol 2008 (Arenaviridae Infections) : RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses ... In conclusion, our data demonstrate a critical role for RIP2 in Nod signaling, while T cell proliferation, T helper differentiation and TLR responses were unaffected by the absence of RIP2
Krieg et al., Proc Natl Acad Sci U S A 2009 : Both NOD1 and NOD2 associated with XIAP in a RIP2 dependent manner, providing evidence that XIAP associates with the NOD signalosome
Homer et al., J Biol Chem 2012 (MAP Kinase Signaling System...) : We examined the requirement of NOD2 signaling mediated by RIP2 for anti-bacterial autophagy induction and clearance of Salmonella typhimurium in the intestinal epithelial cell line HCT116
Ver Heul et al., J Biol Chem 2013 : These data suggest that Ub binding provides a negative feedback loop upon NOD dependent activation of RIP2