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FXR2 — PPARGC1A

Text-mined interactions from Literome

Zhang et al., Genes Dev 2004 : PGC-1alpha increases FXR activity through two pathways : ( 1 ) it increases FXR mRNA levels by coactivation of PPARgamma and HNF4alpha to enhance FXR gene transcription ; and ( 2 ) it interacts with the DNA binding domain of FXR to enhance the transcription of FXR target genes
Kanaya et al., Biochem J 2004 : The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand dependent manner ... Transcriptional activation of the SHP ( small heterodimer partner ) gene by the FXR-RXRalpha ( retinoid X receptor alpha ) heterodimer was also enhanced by PGC-1alpha in the presence of CDCA ( chenodeoxycholic acid ) ... These observations indicate that PGC-1alpha mediates the ligand dependent activation of FXR and transcription of SHP gene