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APLN — TNF
Text-mined interactions from Literome
Daviaud et al., FASEB J 2006
(Inflammation...) :
Since obesity and insulin resistance are associated with chronically elevated levels of both insulin and TNFalpha, the present study was performed to investigate a putative
regulation of
apelin expression in adipocytes by
TNFalpha ...
Apelin regulation by
TNFalpha was further studied in cultured explants of human adipose tissue
Carpéné et al., J Physiol Biochem 2007
(Cardiovascular Diseases...) :
In this regard, expression of
apelin gene in adipose tissue is
increased by insulin and
TNFalpha
Leeper et al., Am J Physiol Heart Circ Physiol 2009
(Aortic Aneurysm, Abdominal...) :
Apelin stimulation of cultured macrophages significantly
reduced MCP-1 and
TNF-alpha mRNA levels relative to baseline ( 2.03- and 1.89-fold reduction, P < 0.03, respectively ) but did not affect intimal adhesion molecule expression or medial or adventitial cell cytokine production