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UCSC Genome Browser Gene Interaction Graph
Gene interactions and pathways from curated databases and text-mining

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APLN — TNF

Text-mined interactions from Literome

Daviaud et al., FASEB J 2006 (Inflammation...) : Since obesity and insulin resistance are associated with chronically elevated levels of both insulin and TNFalpha, the present study was performed to investigate a putative regulation of apelin expression in adipocytes by TNFalpha ... Apelin regulation by TNFalpha was further studied in cultured explants of human adipose tissue
Carpéné et al., J Physiol Biochem 2007 (Cardiovascular Diseases...) : In this regard, expression of apelin gene in adipose tissue is increased by insulin and TNFalpha
Leeper et al., Am J Physiol Heart Circ Physiol 2009 (Aortic Aneurysm, Abdominal...) : Apelin stimulation of cultured macrophages significantly reduced MCP-1 and TNF-alpha mRNA levels relative to baseline ( 2.03- and 1.89-fold reduction, P < 0.03, respectively ) but did not affect intimal adhesion molecule expression or medial or adventitial cell cytokine production