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BDNF — EGR1
Text-mined interactions from Literome
Calella et al., Neural development 2007
:
Genetic depletion of Trk receptors led to impaired recruitment of C/EBPs and NeuroD in vivo, and elimination of Cebpa and Cebpb alleles reduced
BDNF induction of Fos,
Egr1 and Egr2 in primary neurons
Keilani et al., J Neurosci 2012
:
Importantly,
brain derived neurotrophic factor (BDNF), a known inducer of DARPP-32 and Egr-1 expression,
enhanced Egr-1 binding to H10 in vitro
Kwapiszewska et al., Am J Pathol 2012
(Disease Models, Animal...) :
BDNF stimulation of PASMC in vitro
resulted in increased proliferation, TrkB and ERK1/2 phosphorylation, and nuclear translocation of the transcription factor
early growth response factor 1 (Egr-1)
Nakagawara et al., Mol Cell Biol 1994
(Neuroblastoma) :
BDNF also
induces expression of the immediate-early genes c-FOS and
NGFI-A but not NGFI-B or NGFI-C