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CALM2 — NOS2

Pathways - manually collected, often from reviews:

• KEGG Calcium signaling pathway: CALM1/CALM2/CALM3/CALML3/CALML5/CALML6 → NOS1/NOS2/NOS3 (protein-protein, binding/association)

Text-mined interactions from Literome

Wiley et al., Eur J Pharmacol 1999 : Release of nitric oxide occurs as a consequence of glutamate stimulation of NMDA receptors and is dependent upon calcium-calmodulin activation of the enzyme nitric oxide synthase
Weeks et al., Am J Obstet Gynecol 1999 (Calcium Signaling) : Myometrial nitric oxide synthase was 88 % calcium dependent but only partially calmodulin dependent
Massmann et al., Am J Obstet Gynecol 1999 : The biochemical characterization of nitric oxide synthase indicated that the predominant form of nitric oxide synthase in endometrium and myometrium ( 80 % -90 % ) was calcium-calmodulin dependent
Palumbo et al., J Neurochem 1999 : A calcium/calmodulin dependent nitric oxide synthase , NMDAR2/3 receptor subunits, and glutamate in the CNS of the cuttlefish Sepia officinalis : localization in specific neural pathways controlling the inking system
Montgomery et al., J Biol Chem 2000 : Removal of a putative inhibitory element reduces the calcium dependent calmodulin activation of neuronal nitric-oxide synthase
Johanson et al., J Neurosci 2000 (Calcium Signaling) : As a consequence, it has been demonstrated to act as an inhibitor of calmodulin dependent neuronal nitric oxide synthase in vitro, although PEP-19 regulation of calmodulin dependent enzymes has never been characterized in intact cells
León et al., Mol Pharmacol 2000 : Structure related inhibition of calmodulin dependent neuronal nitric-oxide synthase activity by melatonin and synthetic kynurenines
Brokx et al., J Biol Chem 2001 : The calmodulin dependent protein kinase I, constitutive ( cerebellar ) nitric-oxide synthase , and melittin peptides have DeltaC ( p ) values clustered around -3.2 kJ.mol ( -1 ) .K ( -1 ), consistent with the formation of a globular CaM-peptide complex in the canonical fashion
Song et al., Biochem J 2001 : Heat-shock protein 90 augments neuronal nitric oxide synthase activity by enhancing Ca2+/calmodulin binding
Fleming et al., Circ Res 2001 : Phosphorylation of Thr ( 495 ) regulates Ca ( 2+ ) /calmodulin dependent endothelial nitric oxide synthase activity
Homoncik et al., Blood Coagul Fibrinolysis 2003 : In summary, Ca(II)3 ( 3,5-DIPS ) 6, a new calmodulin dependent nitric oxide synthase activator, decreases P-selectin expression of human platelets in response to thrombin receptor activation
Golombek et al., Frontiers in bioscience : a journal and virtual library 2003 : A key second messenger in circadian photic entrainment is calcium, mobilized through membrane channels or intracellular reservoirs, which triggers the activation of several enzymes, including a calcium/calmodulin dependent protein kinase and nitric oxide synthase
Iida et al., J Biol Chem 1992 (Gram-Positive Bacterial Infections) : Identification of inducible calmodulin dependent nitric oxide synthase in the liver of rats ... A calmodulin dependent nitric oxide synthase was significantly induced in the liver of rats treated intravenously with heat killed Propionibacterium acnes and 5 days later with Escherichia coli lipopolysaccharide
Lyons et al., J Biol Chem 1992 : Comparison of the deduced amino acid sequence to the calcium/calmodulin dependent nitric oxide synthase previously purified ( Bredt, D. S., and Synder, S.H. ( 1990 ) Proc. Natl. Acad. Sci. U. S. A. 87, 682-685 ) and cloned ( Bredt, D. S., Hwang, P. M., Glatt, C. E., Lowenstein, C., Reed, R. R., and Synder, S. H. ( 1991 ) nature 351, 714-718 ) from rat brain identifies shared binding sites for the cofactors NADPH and flavins in the C-terminal half of both proteins and an additional conserved region near the N terminus that may recognize L-arginine and/or contribute to the active site
Schini et al., J Pharmacol Exp Ther 1992 : Inhibitors of calmodulin impair the constitutive but not the inducible nitric oxide synthase activity in the rat aorta ... These observations indicate that calmodulin inhibitors inhibit the constitutive but not the inducible nitric oxide synthase ( s ) in the rat aorta
Klatt et al., J Biol Chem 1992 : Ca2+/calmodulin dependent cytochrome c reductase activity of brain nitric oxide synthase
Wolff et al., Biochem J 1992 : Identification and characterization of a calmodulin dependent nitric oxide synthase from GH3 pituitary cells
Oguchi et al., FEBS Lett 1992 : Ca2+/calmodulin dependent nitric oxide synthase was found to be induced during rat liver necrosis caused by administration of Propionibacterium acnes and E. coli lipopolysaccharide to rats
Yan et al., Neurosci Lett 2004 (Brain Ischemia) : Postsynaptic density protein 95 mediates Ca2+/calmodulin dependent protein kinase II-activated serine phosphorylation of neuronal nitric oxide synthase during brain ischemia in rat hippocampus
Agostino et al., Neurochem Int 2004 : Diurnal, circadian and photic regulation of calcium/calmodulin dependent kinase II and neuronal nitric oxide synthase in the hamster suprachiasmatic nuclei
Heinrich et al., Eur Arch Otorhinolaryngol 2004 : Recently, the two Ca ( 2+ ) /calmodulin regulated nitric oxide synthase isoforms, nNOS and eNOS, and NO itself have been identified in the cochlea of vertebrates using specific antibodies and a new fluorescence indicator
Izumi et al., J Cell Biochem 2004 (Liver Neoplasms) : Ca ( 2+ ) /calmodulin dependent nitric oxide ( NO ) synthase activity in wild-type cells was significantly increased by culture with TNF-alpha ( 10 ng/ml ) for 48 or 72 h
Izumi et al., J Cell Biochem 2004 (Carcinoma, Hepatocellular) : Ca ( 2+ ) /calmodulin dependent nitric oxide ( NO ) synthase activity was significantly decreased by culture with LPS ( 1.0 microg/ml ) for 24-72 h of wild-type cells
Yamamoto et al., J Comp Physiol B 2004 : Ca2+, calmodulin and phospholipids regulate nitricoxide synthase activity in the rabbit submandibular gland
Bodnárová et al., J Inorg Biochem 2005 : Calcium/calmodulin dependent nitric oxide synthase activity in the CNS of Aplysia californica : biochemical characterization and link to cGMP pathways
Omoni et al., Mol Nutr Food Res 2006 : Effect of cationic flaxseed protein hydrolysate fractions on the in vitro structure and activity of calmodulin dependent endothelial nitric oxide synthase
Rasbach et al., J Biol Chem 2007 (Reperfusion Injury) : Inhibition p38 MAPK blocked the up-regulation of PGC-1alpha following oxidant injury, whereas inhibition of calcium-calmodulin dependent protein kinase, calcineurin A, nitric-oxide synthase , and phosphoinositol 3-kinase had no effect
Busse et al., Basic Res Cardiol 1991 : The results indicate that Ca ( 2+ ) -calmodulin directly activates the endothelial nitric oxide synthase , thereby transducing agonist induced increases in intracellular free Ca2+ concentration to nitric oxide formation from L-arginine, K ( + ) -induced depolarization of the endothelial cells markedly inhibited the sustained, but not initial phase of the intracellular Ca2+ response to bradykinin, indicating that K ( + ) -induced depolarization depresses the transmembrane Ca2+ influx
Nakane et al., Biochem Biophys Res Commun 1991 : These findings indicate that brain nitric oxide synthase activity may be regulated not only by Ca2+/calmodulin and several co-factors, but also by phosphorylation
Mariotti et al., Int J Immunopathol Pharmacol 2008 : Since cytosolic EDF-1 binds and sequesters calmodulin , an important regulator of endothelial nitric oxide synthase , these results might explain why we do not observe any induction of nitric oxide in endothelial cells exposed to HIV-Tat
Kazimierczuk et al., Arch Pharm Res 2010 : At 10 muM concentration, S- ( 3,4-dichlorobenzyl ) isothiourea hydrochloride and S- ( 2,3,4,5,6-pentabromobenzyl ) isothiourea hydrobromide inhibited Ca ( 2+ ) /calmodulin dependent ( non-inducible ) nitric oxide synthase activity in normal rat brain homogenates stronger ( p < 0.05 ) than the reference drug 7-nitroindazole ( by 78, 76 and 60 %, respectively ) ; ten other new isothiourea derivatives significantly inhibited the activity to a lower extent ( by 28-60 % )
Wu et al., PloS one 2012 : Lobe-specific calcium binding in calmodulin regulates endothelial nitric oxide synthase activation
Bagetta et al., Biochem Biophys Res Commun 1993 : Combined administration of LiCl and tacrine also produced an approx. 80 % increase in Ca ( 2+ ) -calmodulin dependent nitric oxide synthase activity
Hecker et al., J Neurochem 1994 : In contrast to the predominantly particulate, Ca2+/calmodulin dependent nitric oxide ( NO ) synthase in endothelial cells, the corresponding neuronal isoenzyme is considered to be mainly soluble, presumably owing to the lack of a posttranslational myristoylation
Hecker et al., Biochem J 1994 : Endothelial cells ( EC ) contain a constitutive Ca2+/calmodulin dependent nitric oxide ( NO ) synthase ( cNOS ) which plays an important role in the local control of vascular tone
Davda et al., Eur J Pharmacol 1994 : These studies indicate that protein kinase C modulates the activity of the constitutive Ca2+/calmodulin dependent endothelial nitric oxide synthase in the basal state and following agonist stimulation through direct inhibition of the enzyme as well as receptor desensitization
Wolff et al., Arch Biochem Biophys 1994 : 1-Phenylimidazole inhibited citrulline formation by the murine macrophage nitric oxide synthase competitively versus ( 6R ) -5,6,7,8-tetrahydro-L-biopterin ( THB ) with a Ki value of 0.7 microM, but inhibited citrulline formation by Ca ( 2+ ) -calmodulin dependent nitric oxide synthase from GH3 pituitary cells noncompetitively versus THB with a Ki value of 40 microM ... Ca ( 2+ ) -calmodulin dependent nitric oxide synthase from GH3 pituitary cells exhibited a Kact for THB of 80 nM, while the inducible murine macrophage nitric oxide synthase exhibited a Kact of 8 microM
Wolff et al., Arch Biochem Biophys 1994 : Citrulline formation by Ca ( 2+ ) -calmodulin (CaM) dependent nitric oxide synthase from bovine brain is inhibited reversibly by indazole, 5-nitro-, 6-nitro-, and 7-nitroindazole with IC50 values of 2.3 mM, 1.15 mM, 40 microM, and 2.5 microM, respectively
Koch et al., EMBO J 1994 (Synaptic Transmission) : Functional coupling of a Ca2+/calmodulin dependent nitric oxide synthase and a soluble guanylyl cyclase in vertebrate photoreceptor cells
Xie et al., J Leukoc Biol 1994 : The iNOS from murine macrophages tightly binds calmodulin as a subunit, and its activity is not dependent on exogenous calmodulin or elevated calcium
Nagafuji et al., Acta Neurochir Suppl (Wien) 1994 (Brain Damage, Chronic...) : Temporal profiles of Ca2+/calmodulin dependent and -independent nitric oxide synthase activity in the rat brain microvessels following cerebral ischemia
Müller et al., Eur J Neurosci 1994 (Vision, Ocular) : Ca2+/calmodulin dependent nitric oxide synthase in Apis mellifera and Drosophila melanogaster
Martzen et al., J Neurochem 1995 : The target employed was the calcium/calmodulin dependent form of nitric oxide synthase , which is produced by several different types of neurons
Dawson et al., Ann Neurol 1995 : The prevention of glutamate neurotoxicity in cortical cultures by gangliosides closely parallels their potencies in binding calmodulin and inhibiting nitric oxide synthase
Regulski et al., Proc Natl Acad Sci U S A 1995 : Molecular and biochemical characterization of dNOS : a Drosophila Ca2+/calmodulin dependent nitric oxide synthase
Werner-Felmayer et al., Biochem J 1993 (Uterine Cervical Neoplasms) : Ca2+/calmodulin dependent nitric oxide synthase activity in the human cervix carcinoma cell line ME-180
Wolff et al., J Biol Chem 1993 (Pituitary Neoplasms) : The dual mode of inhibition of calmodulin dependent nitric-oxide synthase by antifungal imidazole agents
Michel et al., Proc Natl Acad Sci U S A 1993 : In the vascular endothelium, diverse cell surface receptors are coupled to the Ca2+/calmodulin dependent activation of nitric oxide ( NO ) synthase
Furfine et al., Biochemistry 1993 : L-NG-Nitroarginine ( NA ) inhibited both the L-arginine oxidation and the L-arginine independent NADPH oxidation reactions catalyzed by the calcium/calmodulin dependent constitutive nitric oxide synthase ( cNOS ) from bovine brain
Adachi et al., Eur J Biochem 1993 : Molecular cloning of a cDNA encoding an inducible calmodulin dependent nitric-oxide synthase from rat liver and its expression in COS 1 cells ... The full-length cDNA was expressed in COS 1 cells under the control of a cytomegalovirus promoter and the expressed enzyme was found to be a calmodulin dependent nitric-oxide synthase
Kogan et al., Brain Res 1995 (Substance Withdrawal Syndrome) : LTGD was blocked by either lowering extracellular Ca2+ concentrations or by treatment with the protein kinase C inhibitor chelerythrine but not by inhibitors of calcium/calmodulin dependent kinase or nitric oxide synthase
Slemmon et al., J Biol Chem 1996 : Furthermore, using the calmodulin dependent enzyme neuronal nitric oxide synthase , we demonstrate that native PEP-19 is also an antagonist of enzyme activity
Zoche et al., Biochemistry 1996 : The neuronal nitric oxide synthase and the macrophage nitric oxide synthase are differently regulated by Ca2+/calmodulin
Joshi et al., Pharmacol Toxicol 1996 : This activity was inhibited by N-monomethyl-L-arginine ( NMMA ), nitroarginine, N-6-aminohexyl-5-chloro-1-napthalene sulfonamide ( W-7 ), a calmodulin antagonist, suggesting that the nitric oxide synthase activity is calmodulin dependent
Persechini et al., J Biol Chem 1996 : Replacement of EF hand I by III reduces calmodulin dependent activation of cerebellar nitric oxide synthase activity by 50 %
Bicker et al., Eur J Neurosci 1996 (Second Messenger Systems) : Nitric oxide is generated by a Ca2+/calmodulin stimulated nitric oxide synthase and activates soluble guanylyl cyclase
Agulló et al., Eur J Pharmacol 1997 : Cyclic GMP ( cGMP ) formation induced by agonist stimulation of Ca2+/calmodulin dependent nitric oxide ( NO ) synthase type I is known to occur in both granule cell and astrocyte cultures from rat cerebellum
Michel et al., J Biol Chem 1997 : Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin
Mitsui et al., Arch Oral Biol 1997 : These findings suggest that the rabbit parotid glands are useful for studying the regulation of nitric oxide generation by Ca2+/calmodulin dependent nitric oxide synthase in salivary glands
Feron et al., Curr Opin Nephrol Hypertens 1999 : Nitric oxide production by the Ca2+/calmodulin dependent enzyme endothelial nitric oxide synthase primarily reflects changes in intracellular [Ca2+ ], increasing as Ca2+ rises and decreasing as Ca2+ falls ... This simplistic bimodal mechanism of regulation has recently been refined by the finding that the binding of Ca2+/calmodulin to endothelial nitric oxide synthase involves the disruption of the association of endothelial nitric oxide synthase from the scaffolding protein caveolin and the subsequent translocation of the enzyme from plasmalemmal caveolae
Goren et al., J Mol Cell Cardiol 1998 (Autoimmune Diseases...) : The inhibitors of protein kinase C activity ( staurosporine ) but not calcium/calmodulin ( trifluoperazine ) attenuated the iNOS activity