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BMP7 — PRG4
Text-mined interactions from Literome
Loeser et al., J Rheumatol 2003
(Osteoarthritis) :
In contrast, compared to controls,
OP-1 at 100 ng/ml
stimulated a 3-fold increase in matrix
proteoglycan at day 21 of culture
Zhang et al., Am J Phys Med Rehabil 2004
:
OP-1 stimulates
proteoglycan accumulation by bovine IVD cells isolated from all three zones of the bovine IVDs
Zhang et al., Am J Phys Med Rehabil 2005
:
Low-dose interleukin-1 partially counteracts
osteogenic protein-1 induced
proteoglycan synthesis by adult bovine intervertebral disk cells
Andrades et al., Arthritis Res Ther 2012
:
Induction of superficial zone protein ( SZP )
/lubricin/PRG 4 in muscle derived mesenchymal stem/progenitor cells by transforming growth factor-ß1 and
bone morphogenetic protein-7 ... The present investigation was initiated to determine the
induction of
SZP/lubricin in skeletal muscle derived mesenchymal stem/progenitor cells ( MDMSCs ) by transforming growth factor-ß1 ( TGF-ß1 ) and
bone morphogenetic protein-7 (BMP-7) ... The present investigation demonstrated the efficient and reproducible
induction of
SZP/lubricin accumulation by TGF-ß1 and
BMP-7 in skeletal MDMSCs. Optimization of the experimental conditions may permit the utility of MDMSCs in generating surface zone-like cells with phenotypic markers of AC and, therefore, constitute a promising cell source for tissue engineering approaches of superficial zone cartilage
Flechtenmacher et al., Arthritis Rheum 1996
:
To study the
effects of recombinant human
osteogenic protein-1 ( rHuOP-1 ; bone morphogenetic protein-7 ) on
proteoglycan and collagen synthesis by human articular chondrocytes
Lietman et al., J Bone Joint Surg Am 1997
:
Stimulation of
proteoglycan synthesis in explants of porcine articular cartilage by recombinant
osteogenic protein-1 ( bone morphogenetic protein-7 ) ... The
stimulation of
proteoglycan synthesis by
osteogenic protein-1 ( bone morphogenetic protein-7 ) in explants of cartilage maintained in chemically defined serum-free medium implies that recombinant osteogenic protein-1 may play a role in the maintenance of a steady-state concentration of proteoglycans in articular cartilage, a desirable prerequisite for optimum repair of cartilage
Wu et al., J Cell Biochem 1997
:
Alone,
OP-1 caused approximately 2-fold increase in
proteoglycan synthesis into both the medium and the cell : matrix layer
Huch et al., Arthritis Rheum 1997
:
Effects of recombinant human
osteogenic protein 1 on the production of
proteoglycan , prostaglandin E2, and interleukin-1 receptor antagonist by human articular chondrocytes cultured in the presence of interleukin-1beta