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IL2 — LTA
Text-mined interactions from Literome
Reddy et al., Int Immunol 2001
:
IL-2 induced tumor necrosis factor
(TNF)-beta expression : further analysis in the IL-2 knockout model, and comparison with TNF-alpha, lymphotoxin-beta, TNFR1 and TNFR2 modulation
Plitnick et al., Clin Diagn Lab Immunol 2001
:
Flow cytometric analysis revealed that
IL-2 binding to T cells is inhibited in the
presence of purified
LTA but not LTA plus anti-LTA monoclonal antibody
Xu et al., Biochem Biophys Res Commun 2001
:
The p38 MAPK pathway is involved in the
IL-2 induction of
TNF-beta gene via the EBS element ... Furthermore, using kinase inhibitors, we revealed that p38 MAP kinase is involved in the formation of -130EBS-protein complex and the subsequent transcriptional activation of
TNF-beta gene in
response to
IL-2 stimulation ... Taken together, our results suggested that the complicated
IL-2 induction of
TNF-beta gene expression requires not only the activation of JAK-STAT pathway on the -200GAS element, but also the cooperation of another signal pathway on the -130EBS element
Morath et al., Infect Immun 2002
:
After purification, the commercial
LTA from Bacillus subtilis and S. pyogenes but not LTA from S. aureus
induced the release of tumor necrosis factor alpha,
interleukin 1 beta (IL-1beta), IL-6, and IL-10 in human blood
Limb et al., Immunology 1992
:
The mean fluorescence intensity ( MFI ) of monocyte CD11a was enhanced by
interleukin-2 (IL-2) , TNF-alpha and TNF-beta, and that of CD11b, CD11c and CD18 was
increased by IL-2, IL-4, TNF-alpha and
TNF-beta
Weil et al., Mol Cell Biol 1990
:
As a consequence, there was a delay in the appearance of cytoplasmic messengers after the transcriptional
induction of
TNF beta by
IL-2
Jana et al., Immunology 2009
:
Induction of
lymphotoxin-alpha by
interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70
Som et al., Clinical and vaccine immunology : CVI 2012
(Disease Models, Animal...) :
Anti-inflammatory SMAMPs prevented the induction of tumor necrosis factor (TNF),
interleukin 6 (IL-6), and IL-10 in
response to S. aureus or
LTA , but no other TLR2 ligands
Weil et al., Oncogene Res 1988
:
This led us to investigate the
regulation by
IL2 of TNF-alpha,
TNF-beta , and interferon-gamma (IFN-gamma) mRNA
Palladino et al., Ciba Found Symp 1987
(Neoplasms, Experimental) :
Apart from their direct cytotoxic/cytostatic activities against tumours in vitro and in vivo, the in vivo antitumour activities of TNF-alpha or
TNF-beta may
involve the following biological activities : the induction of
interleukin 1 production ; activation of polymorphonuclear neutrophil functions ; modulation of endothelial cell functions ; and augmentation of specific immune functions
Heaton et al., Cancer Res 1993
:
These data suggest the interaction of
IL-2 and the high-affinity IL-2 receptor on human PBMC or peripheral blood lymphocyte is
required for maximal secretion of IL-1 beta, TNF-alpha,
TNF-beta , and IFN-gamma
Sugiyama et al., Infect Immun 1996
:
In contrast, LPS
induced interleukin 1 activity in human gingival epithelial cells in culture, while
LTA had little effect
Poulsen et al., Cytokine 1996
(Dermatitis, Atopic...) :
The combination ION + PMA
induced the highest levels of
IL-2 , IL-4, IL-5, IFN-gamma and TNF-alpha, whereas maximal production of IL-6 and
TNF-beta were induced by PHA and PHA + PMA, respectively
Lu et al., Eur J Immunol 1998
:
Furthermore, in BA/F3 cells co-transfected with the STAT5A gene and IL-2R beta gene, the
activation of the
TNF-beta gene promoter by
IL-2 was greatly promoted, whereas the TNF-beta gene promoter became IL-2-non-inducible if the STAT5A gene was substituted with a dominant negative STAT5A, i.e. a C-terminally truncated mutant
Worm et al., Immunology 1998
(Hypersensitivity) :
Stimulation of human B cells with anti-CD40
+ interleukin-4 ( IL-4 )
results not only in proliferation and immunoglobulin E ( IgE ) -production, but also increased production of the cytokine lymphotoxin-alpha
(LT-alpha) ( formerly also known as tumour necrosis factor-beta (TNF-beta) )