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ANG — INS

Text-mined interactions from Literome

Chen et al., Endocrinology 2001 : The present studies aim to investigate whether insulin regulates ANG gene expression in kidney proximal tubular cells at the transcription level via interaction of the putative insulin-response element (IRE) with its binding protein ( s ) in the 5'-flanking region of the ANG gene ... These studies demonstrate that insulin action on ANG gene expression is at the transcriptional level
S-L Zhang et al., J Endocrinol 2002 (Diabetes Mellitus, Experimental...) : Kidney proximal tubules were isolated and cultured in either normal glucose ( i.e. 5 mM ) or high glucose ( i.e. 25 mM ) medium to determine the inhibitory effect of insulin on ANG gene expression
Motley et al., Hypertension 2003 : From these data, we conclude that Ang II negatively regulates the insulin signal, Akt, in the vasculature specifically through PKC-alpha activation, providing an alternative molecular mechanism that may explain the association of hyperinsulinemia with cardiovascular diseases
Hsieh et al., J Endocrinol 2004 : In the present study we investigated whether hyperglycaemia induced resistance to the insulin induced inhibition of expression of the ANG gene is mediated via the generation of reactive oxygen species ( ROS ) in RPTCs. Rat IRPTCs were cultured for 2 weeks in high-glucose ( 25 mM ) or normal-glucose ( 5 mM ) medium plus angiotensin II (Ang II) with or without a superoxide scavenger ( tiron ), or inhibitors of : NADPH oxidase ( diphenylene iodinium, DPI ), Ang II type 1 and 2 receptors ( losartan and PD123319 ), angiotensin converting enzyme ( perindopril ), protein kinase C ( GF 109203X ), or glutamine : fructose-6-phosphate amino-transferase ( azaserine ) ... Prolonged exposure of IRPTCs to high concentrations of glucose or Ang II evoked generation of ROS and resistance to the insulin induced inhibition of expression of the ANG gene and of p44/42 MAPK phosphorylation
Stragier et al., J Neurochem 2006 (Seizures) : The anti-convulsant properties of angiotensin IV (Ang IV) , an inhibitor of insulin regulated aminopeptidase (IRAP) and somatostatin-14, a substrate of IRAP, were evaluated in the acute pilocarpine rat seizure model
Igarashi et al., Diabetes Res Clin Pract 2007 (Diabetes Mellitus, Experimental...) : However, the phosphorylation of insulin stimulated insulin related substrate (IRS)-1 was suppressed by Ang II, and the suppression was ameliorated by olmesartan, but not PD123,319, in both WF and WL
Rastelli et al., Peptides 2007 (Diabetes Mellitus, Type 2) : Our data allow us to conclude that diabetes impaired the interaction between BK and Ang- ( 1-7 ) and that insulin restores it
Schindler et al., Int J Clin Pharmacol Ther 2008 : Venoconstrictor responses to angiotensin II (Ang II) and phenylephrine, and endothelium dependent response to histamine and insulin , and endothelium independent response to glyceroltrinitrate were compared using the dorsal hand vein compliance method
Arellano-Plancarte et al., Biochem Pharmacol 2010 (Insulin Resistance) : To investigate the potential interactions between the angiotensin II (Ang II) and insulin signaling systems, regulation of IRS-1 phosphorylation and insulin induced Akt activation by Ang II were examined in clone 9 ( C9 ) hepatocytes
Siebelmann et al., J Recept Signal Transduct Res 2010 : ANG IV reduced the increase in blood glucose during a glucose tolerance test with corresponding, albeit smaller effects on plasma insulin
Chow et al., Peptides 2013 (Edema...) : In our previous study, we showed that intrathecal ( i.t. ) administration of angiotensin IV (Ang IV) , an insulin regulated aminopeptidase (IRAP) inhibitor , attenuated inflammatory hyperalgesia in rats
Santos et al., Peptides 2013 : In addition, HFD+Ang- ( 1-7 ) treated rats presented enhanced glucose tolerance, insulin-sensitivity and decreased plasma-insulin levels, as well as a significant decrease in circulating lipid levels