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IFNG — IL23A
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Cleary et al., J Immunol 2003
(Immunologic Deficiency Syndromes...) :
This mutation resulted in the absence of IL-12Rbeta1 protein on PBMC and an inability of T cells to specifically bind IL-12 or produce
IFN-gamma in
response to either IL-12 or
IL-23
Lupuşoru et al., Rev Med Chir Soc Med Nat Iasi 2002
(Inflammation...) :
IL-23 stimulates
IFN gamma production and proliferation in PHA blast T cells, as well as in CD45RO ( memory ) T cells
Jefford et al., Blood 2003
(Melanoma) :
They responded vigorously to CD40L or E coli, expressing cytokines known to
regulate interferon-gamma (IFN-gamma) in T cells ( IL-12p70, IL-18, and
IL-23 ), but required prostaglandin E2 ( PGE2 ) during stimulation to migrate to chemokines
Hoeve et al., Eur J Immunol 2003
:
Whereas
IL-23 promoted
IFN-gamma production by CD4 ( + ) and CD8 ( + ) T cells in controls, IL-12Rbeta1-deficient T cells lacked IL-23 induced IFN-gamma secretion, but responded normally to IL-2, IL-4, IL-15 and IL-18 ... We also show that
induction of
IFN-gamma production by
IL-23 depends upon TCR-ligation and is enhanced by CD28-costimulation
Shan et al., Anticancer Res 2004
(Esophageal Neoplasms) :
IL-23 , a heterodimer composed of p19 and p40 molecule, can also
enhance T cell proliferation and
interferon-gamma production from activated T cells ; however, its effects on NK cells are currently unknown
Kawakami et al., Microbes Infect 2004
(Tuberculosis, Pulmonary) :
Interferon (IFN)-gamma plays an essential role in host defense against infection with Mycobacterium tuberculosis, and its synthesis is critically
regulated by interleukin (IL)-12, IL-18 and the recently identified
IL-23
Liebau et al., Anticancer Res 2004
(Bone Neoplasms...) :
In contrast to IL-18,
IL-23 showed a moderate increase of IFN-gamma induction when transfected alone and could only slightly
increase the
IFN-gamma induction mediated by IL-12
Piskin et al., Exp Dermatol 2004
(Psoriasis) :
The expression of the type-1 cytokine
interferon-gamma (IFN-gamma) is
regulated by interleukin-12 (IL-12), IL-15, IL-18 and
IL-23 ; however, not much is known about the effect of this therapy on the levels of these cytokines in lesional psoriatic skin in situ ... Thus, we concluded that the decrease of
IFN-gamma expression in psoriasis lesions after NB-UVB therapy could be a
result of diminished expression of IL-12, IL-18 and
IL-23 in lesional skin
Piskin et al., J Immunol 2006
(Psoriasis) :
Functional analysis showed that these low levels of keratinocyte derived
IL-23 were
sufficient to enhance the
IFN-gamma production by memory T cells
Shan et al., Cell Mol Immunol 2006
(Carcinoma...) :
IL-23 also
promoted the production of Th1 cytokines such as
IFN-gamma , IL-12 and TNF-alpha
Overwijk et al., J Immunol 2006
(Weight Loss) :
Although
IL-23 specifically
increased IFN-gamma production by tumor-specific T cells, IFN-gamma itself was not a primary mediator of the vaccine adjuvant effect
Hao et al., Cancer Immunol Immunother 2006
(Neoplasms) :
IL-23 can
enhance the proliferation of memory T cells and the production of
IFN-gamma , IL-12 and TNF-alpha from activated T cells ...
IL-23 can also
induce a lower level of
IFN-gamma production compared with that induced by IL-12
Nembrini et al., J Immunol 2006
:
Upon strong signaling through the TCR, IL-12, IL-18, and
IL-23 play negligible roles in the induction of
IFN-gamma , whereas autocrine IFN-gamma is an important component in sustaining its own secretion
Vaknin-Dembinsky et al., J Immunol 2006
(Multiple Sclerosis) :
Like IL-12,
IL-23 is expressed predominantly by activated dendritic cells (DCs) and phagocytic cells, and both cytokines
induce IFN-gamma secretion by T cells
Oniki et al., Cancer Res 2006
(Melanoma, Experimental) :
In vivo depletion assay revealed that the antitumor effect of
B16/IL-23 was mainly
mediated by CD8+ T cells and
IFN-gamma whereas that of B16/IL-27 mainly involved natural killer cells and was independent of IFN-gamma
Wheeler et al., Immunology 2006
(Encephalomyelitis, Autoimmune, Experimental) :
There was greater expression of
IL-12/23p40 by antigen presenting cells in these mice, and in vitro, TNFR1-/- antigen presenting cells
induced greater secretion of
IFN-gamma but not interleukin (IL)-17 when cultured with primed T cells than did WT antigen presenting cells
Sahiratmadja et al., Infect Immun 2007
(Tuberculosis, Pulmonary) :
Depressed
IFN-gamma production was not
due to decreased
IL-12/IL-23 production
Pedra et al., FEMS Immunol Med Microbiol 2007
(Anaplasmosis...) :
The lack of
IL-12/23p40 reduced
IFN-gamma production in both CD4 ( + ) and CD8 ( + ) T cells although the effect was more pronounced in CD4 ( + ) T cells
Reddy et al., Cell Immunol 2007
:
CNTO 1275 inhibited upregulation of CLA, IL-12R, IL-2Ralpha and CD40L expression and also inhibited IL-12- and
IL-23 induced
IFN-gamma , IL-17A, tumor necrosis factor (TNF)-alpha, IL-2, and IL-10 secretion
Fan et al., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2007
(Autoimmune Diseases) :
The addition of Th2 cytokines ( IL-4 and IL-10 ) or anti-IL-12Rbeta1 mAbs resulted in the inhibition of IL-17 and
IFN-gamma production
induced by
IL-23 ... Further study suggested that
IL-23 , IL-2 and IL-15 directly
induced the production of IL-17 and
IFN-gamma by purified CD4 ( + ) T cells ... The production of IL-17 and
IFN-gamma induced by
IL-23 can be inhibited by Th2 cytokines and anti-IL-12Rbeta1 mAbs
Butchar et al., FEBS Lett 2008
:
IFNgamma enhances
IL-23 production during Francisella infection of human monocytes ... We previously demonstrated that monocytes produce IL-23 during Francisella infection, and that
IL-23 induces
IFNgamma from NK cells
Li et al., Cell Immunol 2008
:
Surprisingly,
IL-23 also
induced IFNgamma by PHA stimulated T-cells and this effect was enhanced in the presence of OX40L
Takedatsu et al., Gastroenterology 2008
(Chronic Disease...) :
Furthermore,
IFN-gamma and IL-17 production from CD4 ( + ) T cells,
induced by IL-12 and
IL-23 respectively, was enhanced synergistically by combination with TL1A
Chizzolini et al., Blood 2008
:
Exogenous PGE ( 2 ) and IL-23 synergized in inducing IL-17, whereas indomethacin and
IL-23 blockade drastically
reduced IL-17 but not
interferon-gamma production
Barkhuizen et al., J Infect Dis 2008
(Parasitemia...) :
Taken together, these results show that, during T. congolense infection, the absence of IL-12, but not the IL-12p80 homodimer or
IL-23 ,
leads to a reduction in
IFN-gamma production, which reduces hepatic pathology and improves host survival in conjunction with IL-10 without negatively affecting parasitemia control
Mo et al., J Immunol 2008
(Encephalomyelitis, Autoimmune, Experimental...) :
Signal transducer and activator of transcription 4 ( Stat4 ) is a transcription factor
activated by IL-12 and
IL-23 , two cytokines known to play important roles in the pathogenesis of EAE by inducing T cells to secrete
IFN-gamma and IL-17, respectively
van de Wetering et al., Int Immunol 2009
:
Herein, we characterized the
effect of
IL-23 on
IFN-gamma secretion by NK and NK-like T cells
Cooper et al., Immunol Rev 2008
(Tuberculosis) :
IL-23 can
induce IFN-gamma responses in the lung if IL-12 is not present, but its major role is in supporting the IL-17 response within the lung
Colić et al., Mol Immunol 2009
(Inflammation...) :
IL-23 stimulated the production of IL-17 by PL-MNC, whereas the secretion of
IFN-gamma was
enhanced by both IL-12 and
IL-23
Kleinschek et al., J Exp Med 2009
(Crohn Disease...) :
CD161 ( + ) CD4 T cells from CD patients readily produce IL-17 and
interferon gamma upon
stimulation with
IL-23 , whereas, in healthy subjects, priming by additional inflammatory stimuli such as IL-1beta was required to enable IL-23 induced cytokine release
Reay et al., Cancer Gene Ther 2009
(Fibrosarcoma) :
In addition, we have shown that the antitumor activity of
IL-23 is independent of IL-17, perforin and Fas ligand, but
dependent on
interferon-gamma , CD4 ( + ) and CD8 ( + ) T cells
Jang et al., J Leukoc Biol 2009
:
Furthermore, production of
IL-23 in CBDC costimulated with LPS and IL-12
caused CD4 ( + ) CD45RO ( + ) memory cells to increase
IFN-gamma production
Cornelissen et al., Arthritis Res Ther 2009
(Arthritis, Experimental) :
Interestingly,
IL-23 was also
critical for the induction of IL-17A and RORgammat but not
IFN-gamma in TCRgammadelta+ T cells in the inflamed joints
van de Wetering et al., PloS one 2009
(Salmonella Infections) :
Both
IFN-gamma and GM-CSF
enhanced IL-23 production by monocytes in response to TLR agonists, as well as induced IL-12 production
Sheikh et al., J Immunol 2010
(Colitis...) :
IFN-gamma attenuates LPS mediated
IL-23 expression in murine macrophages ... Mechanistically,
IFN-gamma inhibits
Il23a promoter activation through altering NF-kappaB binding and histone modification
Buonocore et al., Nature 2010
(Colitis...) :
Stimulation of colonic leukocytes with
IL-23 induced the production of IL-17 and
interferon-gamma exclusively by innate lymphoid cells expressing Thy1, stem cell antigen 1 (SCA-1), retinoic-acid related orphan receptor ( ROR ) -gammat and IL-23R, and these cells markedly accumulated in the inflamed colon
Teng et al., Proc Natl Acad Sci U S A 2010
(Neoplasm Metastasis...) :
Further investigation revealed that loss of
IL-23 promoted perforin and
IFN-gamma antitumor effector function in both metastasis models examined