García-Alvarez et al., Exp Lung Res 2006
(Pulmonary Fibrosis) :
They also determined the role of mitogen activated protein kinase ( MAPK ) in TIMP3 expression
Leivonen et al., PloS one 2013
(MAP Kinase Signaling System) :
Inhibition of extracellular signal regulated kinase 1/2 ( ERK1/2 ) activation with PD98059 and p38 mitogen activated protein kinase activity by SB203580 resulted in suppression of TGF-ß induced TIMP-3 expression, indicating that ERK1/2 and p38 MAPK mediate the effect of TGF-ß on TIMP-3 expression
Li et al., J Immunol 1998
(Arthritis, Rheumatoid) :
Investigation of the signaling mechanisms revealed that protein tyrosine kinase inhibitors genistein and herbimycin A, as well as the specific mitogen activated protein kinase ( MAPK ) kinase inhibitor PD98059, suppressed OSM induced TIMP-3 message expression, suggesting the involvement of tyrosine kinases and mitogen activated protein kinase cascades in the signaling of OSM leading to TIMP-3 RNA enhancement