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HCL2 — PTGS2

Text-mined interactions from Literome

Takeuchi et al., Dig Dis Sci 2004 (Gastrointestinal Hemorrhage...) : The COX-2 expression induced by indomethacin or SC-560 was inhibited by atropine, even in the presence of exogenous HCl , while omeprazole had no effect
Jang et al., J Biol Chem 2007 (Inflammation...) : These results demonstrate for the first time that GS-HCl inhibits COX-2 activity by preventing COX-2 co-translational N-glycosylation and by facilitating COX-2 protein turnover during translation in a proteasome dependent manner
Park et al., J Physiol Pharmacol 2013 (Inflammation...) : TNF-a increased the expression of COX-2, iNOS and inflammatory cytokines, but GS-HCl significantly attenuated TNF-a induced COX-2 expression