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EDN1 — SRC
Pathways - manually collected, often from reviews:
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC)
→
Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr)(cy) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC)
(translocation, collaborate)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC)
→
dynamin gtpase (DNM1)
(translocation, collaborate)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC)
→
RAS (HRAS)
(modification, activates)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC)
→
None
(modification, activates)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC)
→
None
(modification, activates)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC)
→
dynamin gtpase (DNM1)
(modification, activates)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC)
→
SRC/Hck/c-Fgr (FGR/HCK/SRC)
(modification, collaborate)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC)
→
Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1)
(modification, collaborate)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
SRC/Hck/c-Fgr (FGR/HCK/SRC)
→
Ligand/GPCR(+)/Arrestin complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1)
(modification, collaborate)
-
BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling:
Arrestin/SRC/Hck/c-Fgr complex (ARRB1-FGR_HCK_SRC)
→
Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr)(cy) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC)
(degradation, collaborate)
Text-mined interactions from Literome
He et al., Hypertension 2001
(Cardiovascular Diseases...) :
Src and Rac
mediate endothelin-1 and lysophosphatidic acid stimulation of the human brain natriuretic peptide promoter
Wang et al., J Am Soc Nephrol 2003
:
Stimulation of
c-Src by
endothelin-1 required CaMK II activity, further supporting the notion that CaMK II acts upstream of Src in a signaling cassette