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E2F3 — MYLIP
Text-mined interactions from Literome
Welch et al., Oncogene 2007
(Chromosome Deletion...) :
As a potential mechanistic explanation for this observation, we demonstrate that
miR-34a directly targets the messenger ribonucleic acid ( mRNA ) encoding E2F3 and significantly
reduces the levels of
E2F3 protein, a potent transcriptional inducer of cell-cycle progression
Giannakakis et al., Cancer Biol Ther 2008
(Anoxia...) :
Biocomputational analysis and in vitro assays demonstrated that
e2f transcription factor 3 (e2f3) , a key protein in cell cycle, is
regulated by
miR-210
Aguda et al., Proc Natl Acad Sci U S A 2008
(Neoplasms) :
In return,
E2F and Myc
induce the transcription of
miR-17-92 , thus forming a negative feedback loop in the interaction network
Wu et al., Acta Pharmacol Sin 2011
(Glioma) :
In U251 cells, transfection of a miR-128 inhibitor ( 50 nmol/L ) prevented the overexpression of miR-128 by Rh2, and significantly blunted Rh2 induced cytotoxicity, apoptosis, caspase 3 activation, transcriptional
activation of
E2F3a , a
miR-128 target gene, as well as E2F3a protein expression
Feng et al., Cancer 2012
(Adenocarcinoma...) :
Our results suggest that down-regulation of
miR-200b could
lead to
E2F3 overexpression and in turn contribute to chemoresistance of lung adenocarcinoma cells to docetaxel
Noguchi et al., J Biol Chem 2012
(Melanoma) :
The ectopic expression of
miR-203 in melanoma cells
reduced the levels of E2F3a,
E2F3b , and ZBP-89 protein expression
Yan et al., PloS one 2012
:
In turn,
E2F is
inhibited by
miR449 through regulating different transcripts, thus forming negative feedback loops in the interaction network
Hu et al., Biomaterials 2013
(Pancreatic Neoplasms) :
The up-regulation of
miR-34a remarkably induced cell cycle arrest and apoptosis, suppressed the tumor cell migration and
inhibited the target gene expressions such as
E2F3 , Bcl-2, c-myc and cyclin D1