◀ Back to FGF5
FGF21 — FGF5
Text-mined interactions from Literome
Ito et al., J Cell Physiol 2003
:
We showed the activities on hair growth of the two Fgf-5 gene products, one of which,
FGF-5 suppressed hair growth by inhibiting anagen proceeding and inducing the transition from anagen to catagen, and
FGF-5S , a shorter polypeptide with FGF-5 antagonizing activity translated from alternatively spliced mRNA,
suppressed this activity of FGF-5
Kurosu et al., J Biol Chem 2007
:
Accordingly, FGF19, but not
FGF21 ,
activates FGF signaling in hepatocytes that primarily express FGFR4 and reduces transcription of CYP7A1 that encodes the rate limiting enzyme for bile acid synthesis
Kharitonenkov et al., J Cell Physiol 2008
:
Interestingly,
FGF-21 mediated effects are heparin independent suggesting that betaKlotho plays a role in
FGF-21 activity similar to the one played by heparin in the signaling of conventional FGFs
Lü et al., Chin Med J (Engl) 2010
(Coronary Artery Disease) :
Furthermore,
FGF21 levels increased by 200 µmol/L bezafibrate could reduce CMECs apoptosis, and
inhibit FGF21 expression by shRNA induced apoptosis ( P < 0.05 )
Adams et al., PloS one 2012
:
The scaffold protein ßklotho ( KLB ) has previously been demonstrated in vitro to function as a co-factor permitting
FGF21 mediated
FGF receptor activation
Clements et al., Oncogene 1993
:
Activation of
fibroblast growth factor ( FGF ) receptors by recombinant human
FGF-5