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COL1A2 — IFNG
Text-mined interactions from Literome
Ghosh et al., J Biol Chem 2001
:
Overexpression of p300 restored
COL1A2 stimulation by TGF-beta in the
presence of
IFN-gamma , and potentiated IFN-gamma dependent positive transcriptional responses
Higashi et al., J Biol Chem 2003
:
Also, overexpression of a deletion mutant YB-1, which lacks the carboxyl-terminal domain, abrogated the
repression of
COL1A2 transcription by
IFN-gamma
Higashi et al., J Biol Chem 2003
:
Down-regulation of endogenous YB-1 expression by double stranded YB-1-specific RNA abrogated the transcriptional
repression of
COL1A2 by
IFN-gamma in the absence and presence of TGF-beta ... They also indicate that
IFN-gamma/YB-1 inhibits
COL1A2 transcription by dual actions : via the IFN-gamma response element and through a cross-talk with the TGF-beta/Smad signaling pathway
Xu et al., J Biol Chem 2004
:
In this report, we demonstrate that CIITA is a key mediator of
COL1A2 repression by
IFN-gamma ... This leads to the alleviation of
COL1A2 repression and MHC-II
activation by
IFN-gamma ... Our data suggest that CIITA is a crucial member of a repressor complex responsible for mediating
COL1A2 transcription
repression by
IFN-gamma
Fang et al., Nucleic Acids Res 2009
:
Here we demonstrate that TGF-beta abrogated
COL1A2 repression by
IFN-gamma through altering the relative expression of RFXB and RFXBSV