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IL2 — PRDM1
Text-mined interactions from Literome
Gong et al., J Immunol 2007
:
Cytokine dependent
Blimp-1 expression in activated T cells
inhibits IL-2 production ... Furthermore, ectopic expression of
Blimp-1 by activated T cells
inhibited IL-2 production but enhanced granzyme B and CD25 expression
Martins et al., J Exp Med 2008
:
Blimp-1 directly
represses Il2 and the Il2 activator Fos, attenuating T cell proliferation and survival ... Using these mechanisms Blimp-1 participates in an autoregulatory loop by which
IL-2 induces
Prdm1 expression and thus represses its own expression after T cell activation, ensuring that the immune response is appropriately controlled
Küçük et al., Proc Natl Acad Sci U S A 2011
(Lymphoma, Non-Hodgkin) :
We observed a progressive increase in PRDM1 expression -- in particular,
PRDM1a -- in normal NK cells in
response to
IL-2 and in normal NK cells activated with an engineered NK cell target, K562-Cl9-mb21, suggesting its role in NK cell homeostasis ... We observed a progressive increase in PRDM1 expression -- in particular,
PRDM1a -- in normal NK cells in
response to
IL-2 and in normal NK cells activated with an engineered NK cell target, K562-Cl9-mb21, suggesting its role in NK cell homeostasis