Raya et al., Genes Dev 2003
(Situs Inversus) :
Notch activity induces Nodal expression and mediates the establishment of left-right asymmetry in vertebrate embryos
Takeuchi et al., Proc Natl Acad Sci U S A 2007
:
Notch mediated induction of Nodal at the vertebrate node is a critical step in initiating left-right ( LR ) asymmetry
Hardy et al., Cancer Res 2010
(Melanoma...) :
Surprisingly, Notch4 is specifically required for expression of Nodal in aggressive cells and plays a vital role both in the balance of cell growth and in the regulation of the aggressive phenotype