◀ Back to EGF

EGF — ITGB4

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: ITGB4 → EGF (increases) Olsen et al., Cell 2006*
  Evidence: We have detected 6,600 phosphorylation sites on 2,244 proteins and have determined their temporal dynamics after stimulating HeLa cells with epidermal growth factor (EGF) and recorded them in the Phosida database
• NCI Pathway Database a6b1 and a6b4 Integrin signaling: EGF/EGFR complex (EGF-EGFR) → alpha6/beta4 Integrin complex (ITGA6-ITGB4) (modification, activates)
  Russell et al., J Cell Sci 2003, Yoon et al., Cancer Res 2006
  Evidence: assay

Text-mined interactions from Literome

Song et al., J Cell Biochem 2001 : Injury and EGF mediate the expression of alpha6beta4 integrin subunits in corneal epithelium
Song et al., Cell Tissue Res 2003 : We hypothesized that inhibition of EGF receptor messenger RNA ( mRNA ) would block integrin beta4 expression, which is induced by EGF
Ogawa et al., Mol Biol Cell 2007 : Gamma2sa also suppressed EGF induced tyrosine phosphorylation of integrin beta4 and resultant disruption of hemidesmosome-like structures in keratinocytes