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MMP9 — RLN2

Text-mined interactions from Literome

Naqvi et al., Arthritis Res Ther 2005 : Previously, we showed that relaxin dose-dependently induces matrix metalloproteinase ( MMP ) expression in isolated joint fibrocartilaginous cells
Goldsmith et al., Ann N Y Acad Sci 2005 : In addition, relaxin negatively regulates expression of endometrial matrix metalloproteinases ( MMP ) , causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor, tissue inhibitor of metalloproteinase 1 ... The negative effects of relaxin on MMP expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix
Ho et al., Ann N Y Acad Sci 2005 : In conclusion, these data suggest that relaxin induced MMP-9 expression in THP-1 cells involves NF-kappaB activation
Kamat et al., Cancer Biol Ther 2006 (Carcinoma, Endometrioid...) : RLN stimulation caused a significant increase in levels of activated MMP-2 in KLE cells and activated MMP-9 in HEC-1B cells compared to unstimulated cells
Silvertown et al., Endocrinology 2006 (Lung Diseases) : Taken together, this study provides proof-of- principle that relaxin gene expression targeted to the mouse lungs can result in enhanced MMP activity offering potential for alleviating disease conditions characterized by dysregulation of extracellular matrix protein accumulation
Henneman et al., Arch Oral Biol 2008 : Previous studies have indicated that MMP production can be stimulated by the hormone relaxin
Ahmad et al., Mol Cell Endocrinol 2012 : We determined the precise role of relaxin family peptide ( RXFP ) receptors-1 and -2 in the regulation of MMP-9 and -13 by relaxin, and delineated the signaling cascade that contributes to relaxin 's modulation of MMP-9 in fibrocartilaginous cells ... Suppression or overexpression of RXFP2 resulted in no changes in the relaxin induced MMP-9 and -13 ... Studies using chemical inhibitors and siRNAs to signaling molecules showed that PI3K, Akt, ERK and PKC-? and the transcription factors Elk-1, c-fos and, to a lesser extent, NF-?B are involved in relaxin 's induction of MMP-9
Cao et al., Eur Rev Med Pharmacol Sci 2013 (Breast Neoplasms...) : The relaxin induced increase in MMP-2 and MMP-9 expression was blocked when S100A4 was inhibited by S100A4 siRNA transfection