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Li et al., Am J Physiol 1999
(Lung Diseases) :
In an effort to elucidate the mechanism of gene inactivation, we report in this study that cationic lipid-protamine-DNA ( LPD ) complexes, but not each component alone, can induce a high level of cytokine production, including interferon-gamma and tumor necrosis factor-alpha Pevni et al., Anesthesiology 2001
(Heart Diseases) :
Heparin improved LV recovery and decreased protamine induced TNF-alpha release ( KH > protamine > KH + heparin group ) ... Anti-TNF-alpha antibodies and heparin prevent protamine induced TNF-alpha release and depression of LV function