◀ Back to TNF

SLC22A3 — TNF

Text-mined interactions from Literome

Dong et al., Braz J Med Biol Res 2007 : These results showed that TNF-alpha can promote epithelial-mesenchymal transition (EMT) of MCF-7 cells ... Thus, the activation of NFkappaB, which causes an increase in the expression of the transcription factor Snail is essential in the TNF-alpha induced EMT ... ROS caused by TNF-alpha seemed to play a minor role in the TNF-alpha induced EMT of MCF-7 cells, though ROS per se can promote EMT
Chuang et al., Cancer Sci 2008 (Carcinoma, Renal Cell...) : Moreover, TNF-alpha induced the EMT of 786-O cells by repressing E-cadherin, promoting vimentin expression, and activating MMP9 activity
Liu et al., Cell Motil Cytoskeleton 2008 (Fibrosis...) : IL-1beta or TNF-alpha alone can also augment TGF-beta1 induced EMT
Inumaru et al., Genes Cells 2009 : Finally, we demonstrated that H ( 2 ) O ( 2 ) treatment alone does not induce the epithelial mesenchymal transition (EMT) in retinal pigment epithelial cells, which can be induced by TNF-alpha treatment
Takahashi et al., J Biol Chem 2010 (Fibrosis) : The production of hyaluronan and its interaction with CD44, thus, play an essential role in TNF-alpha induced EMT and are potential therapeutic targets in fibrotic disorders
Yamauchi et al., Exp Lung Res 2010 (Adenocarcinoma, Bronchiolo-Alveolar...) : Therefore, the authors investigated whether TNF-alpha affected TGF-beta1 induced EMT ... In conclusion, TNF-alpha enhances not only EMT but also cell contraction induced by TGF-beta1
Yan et al., Am J Pathol 2010 (Cicatrix...) : Moreover, TNF-alpha induced EMT was impaired by antagonists against bone morphogen proteins (BMP) 2/4, suggesting that BMP mediates the TNF-alpha induced EMT in human skin
Bramlage et al., BMC nephrology 2010 (Hypertension...) : Only high concentrations of BMP-7 ( 100 ng/ml ) were able to reverse TNF-a induced apoptosis and TGF-ß induced EMT in human proximal tubule cells possibly due to a decreased expression of TGF-ßRI
Kamitani et al., Int Arch Allergy Immunol 2011 (Airway Remodeling) : We investigated whether TGF-ß1 and/or TNF-a induce EMT in bronchial epithelial cells ... EMT induced with TGF-ß1 plus TNF-a promoted cell migration
Wu et al., Experimental biology and medicine (Maywood, N.J.) 2011 (Carcinoma, Renal Cell...) : To investigate the role of NF-?B activation in TNF-a induced EMT of RCC, we employed chemical inhibitors ( NF-?B activation inhibitor and Bay 11-7082 ) and transfected dominant negative ( pCMV-I?BaM ) and overexpressive ( pFLAG-p65 ) vectors of NF-?B
Li et al., Cancer Res 2012 (Breast Neoplasms...) : Here we show that EMT and cancer stemness properties induced by chronic treatment with TNF-a are mediated by the upregulation of the transcriptional repressor Twist1
Wan et al., Mol Biotechnol 2013 : This study aimed to determine the EMT inducing activity of proinflammatory cytokine TNF-a and the role for complement 3 ( C3 ) in this activity in an in vitro model of human RTECs ( HK-2 cells ) ... Our preliminary observations suggest that TNF-a may induce EMT in RTECs through inducing C3 expression
Ho et al., Mol Cancer Res 2012 (Carcinoma, Renal Cell...) : Here, we showed that TNF-a induced epithelial-mesenchymal transition (EMT) and promoted tumorigenicity of RCC by repressing E-cadherin, upregulating vimentin, activating MMP9, and invasion activities ... Inhibition of PI3K/AKT by LY294002 reactivated GSK-3ß and suppressed the TNF-a induced EMT of RCC cells
Xiong et al., American journal of physiology. Renal physiology 2012 (Inflammation...) : Ectopic expression of VDR counteracted the synergistic effect of TNF-a and TGF-ß1 on EMT ... Furthermore, knockdown of VDR using a small interfering RNA strategy mimicked the effect of TNF-a on facilitating EMT
Techasen et al., Med Oncol 2012 (Bile Duct Neoplasms...) : The effect of TNF-a on EMT activation in CCA cells was also demonstrated
Wang et al., PloS one 2013 (Colorectal Neoplasms) : Epithelial-mesenchymal transition (EMT) induced by TNF-a requires AKT/GSK-3ß mediated stabilization of snail in colorectal cancer