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Eliseev et al., Exp Cell Res 2006
(Bone Neoplasms...) :
Here, we show that in osteosarcoma Saos2 osteoblasts, NFkappaB regulates the activity of the BMP/Smad signaling ... We therefore conclude that in osteosarcoma Saos2 cells, NFkappaB represses BMP/Smad signaling and BMP2 induced differentiation through Smad7
Sugimori et al., J Bone Miner Metab 2005
:
Thus, BMP-2 induced NF-kappaB activation is mediated by PI3K/Akt signaling
Tintut et al., J Investig Med 2006
(Atherosclerosis...) :
Binding of RANKL to its cognate receptor RANK induces NF-kappaB signaling, which stimulates osteoclastic differentiation in preosteoclasts and induces bone morphogenetic protein ( BMP-2 ) expression in chondrocytes