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FOXO3 — MDM2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Yang et al., Nat Cell Biol 2008
(Breast Neoplasms...) :
Taken together, our study elucidates a novel pathway in cell growth and tumorigenesis through negative
regulation of
FOXO3a by RAS-ERK and
MDM2
Fu et al., J Biol Chem 2009
:
MDM2 promotes the ubiquitination of FOXO1 in a cell-free system, and its knockdown by small interfering RNA
causes accumulation of endogenous
FOXO3A protein in cells and enhances the expression of FOXO target genes