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JUN — MMP7
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Westermarck et al., FASEB J 1999
(Neoplasm Invasiveness...) :
This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the
role of mitogen activated protein kinases and
AP-1 and ETS transcription factors in the regulation of
MMP gene expression during invasion process
Sato et al., Cancer Res 2002
(Fibrosarcoma...) :
These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells, and that the nobiletin mediated inhibition of
activator protein-1 binding activity is at least partly
involved in the suppression of
MMP expression
Kajanne et al., J Cell Physiol 2007
:
Here we provide genetic and biochemical evidence that EGF-R- and
AP-1 mediated signals are
required for
MMP expression and collagen contraction in fibroblasts
Hammaker et al., Arthritis Res Ther 2007
(Arthritis, Rheumatoid) :
c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (
MMP ) gene expression and joint destruction in inflammatory arthritis
Oliver et al., J Rheumatol 2007
(Arthritis, Experimental...) :
We evaluated whether a vanadium
AP-1 inhibitor could
reduce MMP expression and subsequent joint damage in CIA
Kim et al., Biosci Biotechnol Biochem 2007
(Colorectal Neoplasms) :
Although CUR abolished the EGCG upregulated
MMP-7 mRNA expression, it unexpectedly
enhanced the
AP-1 activity by 502 %, suggesting that this factor may disrupt the MMP-7 mRNA stabilization process
Yuan et al., Mol Cell Biochem 2008
:
Our data suggest that HRG-beta induced
MMP-7 expression was
regulated by HER2 mediated
AP-1 activation in MCF-7 cells
Chan et al., International journal of molecular sciences 2011
:
In the current study, pretreatment with nitric oxide ( NO ) scavengers inhibited PDT induced mitochondrial
membrane potential ( MMP ) changes,
activation of caspase-9, caspase-3, p21 activated protein kinase 2 (PAK2) and
c-Jun N-terminal kinase (JNK) , and gene expression of p53 and p21 involved in apoptotic signaling
Ho et al., International journal of biological sciences 2011
(Adenocarcinoma...) :
Moreover, H2O2 triggered
MMP-7 production was demonstrated via JNK/c-Jun and ERK/c-Fos activation in an
activating protein 1 (AP-1) dependent manner ... Taken together, these results suggest that DMA suppresses H2O2 induced cell invasion by inhibiting
AP-1 mediated
MMP-7 gene transcription via the JNK/c-Jun and ERK/c-Fos signaling pathways in SW620 human colon cancer cells
Lee et al., J Dermatol Sci 2013
:
In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent
activation of mitogen activated protein kinase ( MAPK ), ATF-2, and
c-Jun , and
MMP expression