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SP1 — TNF
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Ping et al., J Biol Chem 2000
:
Sp1 binding is
critical for promoter assembly and activation of the MCP-1 gene by
tumor necrosis factor
Tanaka et al., J Biol Chem 2000
:
The receptor for advanced glycation end products is
induced by the glycation products themselves and
tumor necrosis factor-alpha through nuclear factor-kappa B, and by 17beta-estradiol through
Sp-1 in human vascular endothelial cells
Tsai et al., Mol Cell Biol 2000
:
The transcription factors ATF-2, c-jun, Egr-1, and
Sp1 are also inducibly recruited to the TNF-alpha promoter in vivo, and the binding sites for each of these activators are
required for LPS stimulated
TNF-alpha gene expression
Zhang et al., Free Radic Biol Med 2003
:
Intracellular metal ion chelators inhibit
TNFalpha induced
SP-1 activation and adhesion molecule expression in human aortic endothelial cells
Shi et al., J Cardiovasc Pharmacol 2004
:
Electrophoresis mobility shift assay ( EMSA ) and Western blot analysis showed that both the nuclear factor-kappaB (NF-kappaB) and the
specificity protein-1 (SP-1) were
activated by
TNFalpha
Pazdrak et al., Gastroenterology 2004
:
TNFalpha significantly
enhanced Sp1/DNA binding
Hamanaka et al., J Biol Chem 1992
:
Induction of low density lipoprotein receptor and a transcription factor
SP-1 by
tumor necrosis factor in human microvascular endothelial cells
Afonso et al., Free Radic Biol Med 2006
:
In agreement with these findings, EMSA shows a
TNF-alpha induced increase in AP-1 and a decrease in
Sp1 DNA binding
Koga et al., Am J Physiol Lung Cell Mol Physiol 2007
:
TNF-alpha stimulated binding of
Sp1 to the MUC1 promoter in intact cells was demonstrated by chromatin immunoprecipitation assay
Lee et al., Oncol Rep 2008
(MAP Kinase Signaling System...) :
The transactivation of
TNF-alpha stimulated NF-kappaB, AP-1 and
Sp-1 were inhibited by U0126 and SB203580 treatment
Niu et al., Immunology 2011
:
Therefore, we initially speculated that miR-1224 was a negative regulator of
TNF-a in an
Sp1 dependent manner, which was confirmed in vivo by chromatin immunoprecipitation assay, and might be involved in regulating the LPS mediated inflammatory responses
Das et al., Am J Physiol Lung Cell Mol Physiol 2011
(Respiratory Distress Syndrome, Adult) :
TNF-a inhibited TTF-1 but not
Sp1 or hepatocyte nuclear factor-3 DNA binding to TTF-1 promoter ... Transactivation experiments in A549 cells indicated that
TNF-a inhibited TTF-1 promoter activation by exogenous
Sp1 and TTF-1 without altering their levels, suggesting inhibition of transcriptional activities of these proteins
Gualberto et al., J Biol Chem 1995
:
Importantly,
TNF induced the association between p53 and
Sp1 in Jurkat T cells