Huang et al., Mol Cell Biol 2008
:
However, how mTORC2 is regulated and whether the TSC1-TSC2 complex is involved are unknown ... Our data also suggest that the TSC1-TSC2 complex positively regulates mTORC2 in a manner independent of its GTPase activating protein activity toward Rheb ... These data demonstrate that the TSC1-TSC2 complex inhibits mTORC1 and activates mTORC2 , which through different mechanisms promotes Akt activation
Melnik et al., Exp Dermatol 2013
:
Antiandrogens may attenuate mTORC1 by suppressing mTORC2 mediated Akt/TSC2 signalling