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ADAMTS5 — HDAC2

Text-mined interactions from Literome

Fosang et al., Nat Clin Pract Rheumatol 2008 (Osteoarthritis) : Some histone deacetylase inhibitors that are successfully used to treat cancer can block ADAMTS-5 expression ; however, these inhibitors will only be considered as potential therapies for OA if their toxicity is markedly reduced
Saito et al., Osteoarthritis Cartilage 2013 (MAP Kinase Signaling System) : HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM ) suppressed CTS induced expression of RUNX-2, ADAMTS-5 , and MMP-3 at both the mRNA and protein levels within 1h ... HDAC inhibitors ( TSA : 10nM, MS-275 : 100nM ) suppressed CTS induced expression of RUNX-2, ADAMTS-5 , and MMP-3 at both the mRNA and protein levels within 1h ... The CTS induced expression of RUNX-2 and ADAMTS-5 was suppressed by HDAC inhibitors via the inhibition of the MAPK pathway activation in human chondrocytes