Gene interactions and pathways from curated databases and text-mining

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IL10 — PTX3

Text-mined interactions from Literome

Fujimoto et al., Intern Med 1999 (Paraparesis, Tropical Spastic) : PTX treatment induced incremental increases in the levels of IL-4 and IL-10 in both sera and CSF of 6 HAM patients
Marcinkiewicz et al., Immunopharmacology 2000 : PTX also affects the production of other cytokines such as IL-1, IL-6, IL-10 , IL-12, and IFN-gamma ... However, at higher concentrations, PTX inhibited the production of TNF-alpha, IL-10 , and IL-12 p35, but surprisingly, PTX enhanced the production of IL-12 p40
Ji et al., Ann Clin Lab Sci 2004 (Disease Models, Animal...) : At all dosages, PTX reduced the activation of NF-kappaB and the production of TNF-alpha and IL-6, but enhanced the release of IL-10 ... In conclusion, PTX suppressed the production of proinflammatory cytokines such as TNF-alpha and IL-6 in rat intestine, and enhanced the endotoxin induced production of IL-10
Doni et al., J Leukoc Biol 2006 : It was unexpected that lipopolysaccharide (LPS) stimulated PTX3 production was enhanced by IL-10 and inhibited by IL-4 and interferon-gamma (IFN-gamma) ... Enhancement of PTX3 production by IL-10 was also evident when Pam3 Cys-Ser- ( Lys ) 4.3HCl, a TLR2-TLR1 agonist, polyionisicpolycytidylic acid, a TLR3 agonist, and IL-1beta were used as stimuli
Schneider et al., Infect Immun 2007 : Stimulation of T cells with holotoxin ( PTx ) or the B subunit alone ( PTxB ) rapidly induces signaling events resulting in inositol phosphate accumulation, Ca ( 2+ ) mobilization, interleukin-2 (IL-2) production, and mitogenic cell growth
Yamamoto et al., Hemodial Int 2013 (Cardiovascular Diseases...) : While C-reactive protein did not change, interleukin-6 (IL-6) increased by 14 % and pentraxin 3 (PTX3) increased by 45 %
van Furth et al., Clin Diagn Lab Immunol 1995 : The release of IL-10 was significantly reduced by PTX at 24 h and by caffeine at 48 h, but DXM increased the release of this cytokine
Navarro et al., AIDS 1996 : Moreover, PTX reduced TNF-alpha, IFN-gamma and IL-10 production and NF-kappa B activation
Vouret-Craviari et al., Infect Immun 1997 : IL-10 and IL-13 did not inhibit the induction of PTX3 by LAM
Dong et al., J Clin Immunol 1997 : PTX at a 3.5 x 10 ( -5 ) M concentration significantly inhibited T cell proliferation and the production of tumor necrosis factor-alpha, interleukin-2 , and interleukin-4
D'Hellencourt et al., Int J Immunopharmacol 1996 : We investigated PTX effects on production and mRNA expression of TNF alpha, IL-1 beta, IL-6, IL-8, TNF beta and IL-10 ... We also noted that the effects of PTX on IL-6, IL-8 and IL-10 production were different in WB and in PBMC culture
Schratzberger et al., Immunopharmacology 1999 : In the present study, we investigated the effects of the anti-inflammatory drug pentoxifylline ( PTX ) on activation of endothelial cells for enhanced adhesion and transmigration of neutrophils by lipopolysaccharide (LPS), tumor necrosis factor-alpha (TNF), interleukin-1 (IL-1) and granulocyte colony stimulating factor ( G-CSF )