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IL10 — STAT1

Text-mined interactions from Literome

Ito et al., Blood 1999 : Interleukin-10 inhibits expression of both interferon alpha- and interferon gamma- induced genes by suppressing tyrosine phosphorylation of STAT1 ... Therefore, IL-10 can directly inhibit STAT dependent early response gene expression induced by both IFNalpha and IFNgamma in monocytes by suppressing the tyrosine phosphorylation of STAT1
Subramaniam et al., Biochem Biophys Res Commun 1999 : Immunoprecipitation with specific antibodies followed by Western blot analysis with antiphosphotyrosine antibody has shown that in U937 cells, interleukin-17 induces time dependent stimulation of tyrosine phosphorylation of JAK 1, 2 and 3, Tyk 2 and STAT 1 , 2, 3 and 4 within 0.5 to 30 min. Interleukin-17 mediated tyrosine phosphorylation of these proteins strongly suggests that the JAK/STAT signaling pathway may play a major role in transducing signals from interleukin-17 receptors to the nucleus
Cassatella et al., Blood 1999 : In this study, we report that IL-10 is also unable to induce the binding of STAT1 or STAT3 to the serum-inducible element ( hSIE/m67 ), despite the fact that both proteins are expressed in neutrophils
Lee et al., J Exp Med 1999 : Interestingly, interleukin (IL)-7 selectively activated STAT1 and induced MHC class I in mature T but not B cells
Shen et al., FEBS Lett 2000 : IL-10 attenuates IFN-alpha activated STAT1 in the liver : involvement of SOCS2 and SOCS3 ... These findings suggest that IL-10 inhibits IFN-alpha activated STAT1 in the liver, at least in part, by inducing SOCS2, SOCS3, and CIS expression, which may be responsible for the resistance of IFN-alpha therapy in patients who have high levels of IL-10 and recommends that IL-10 treatment for viral hepatitis should be cautious
Crepaldi et al., J Immunol 2001 : In this study, we report that IL-10 can nonetheless induce Stat3 tyrosine phosphorylation and the binding of Stat1 and Stat3 to the IFN-gamma response region or the high-affinity synthetic derivative of the c-sis-inducible element in neutrophils that have been cultured for at least 3 h with LPS
Ichikawa et al., Biochem Biophys Res Commun 2002 (Carcinoma, Hepatocellular) : In contrast, IL-10 inhibited IFN-alpha mediated tyrosine phosphorylation of STAT1 by induction of a Janus kinase inhibitor, JAB
Sharif et al., J Immunol 2004 (Lupus Erythematosus, Systemic) : IFN-alpha priming resulted in greatly enhanced STAT1 activation in response to IL-10 , and STAT1 was required for IL-10 activation of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma expression in IFN-alpha primed cells ... In control, unprimed cells, IL-10 activation of STAT1 was suppressed by constitutive activity of protein kinase C and Src homology 2 domain containing phosphatase 1
Usui et al., Hematol J 2004 (Multiple Myeloma) : Upregulated production of IL-6, but not IL-10 , by interferon-alpha induces SOCS3 expression and attenuates STAT1 phosphorylation in myeloma cells
Ji et al., Rheumatology (Oxford) 2005 : 15d-PGJ2 blocked IL-10 induced STAT1 and STAT3 activation in primary human monocytes, macrophages and THP-1 cells
Rahimi et al., J Immunol 2005 : By using specific inhibitors for PI3K ( LY294002 ) and ERK MAPKs ( PD98059 ), we demonstrate that LY294002 either alone or in conjunction with PD98059 inhibited IL-10 induced phosphorylation of STAT-1 and consequently CD14 expression
VanDeusen et al., Eur J Immunol 2006 (Gram-Negative Bacterial Infections) : In C57BL/6 mice, early IL-10 induction occurs independently of STAT-1, while a delayed active repression of IL-10 gene expression is critically dependent on STAT-1 , but only partially dependent upon IFN-alpha/beta and IFN-gamma
Cheon et al., J Immunol 2006 : Pretreatment with PGE ( 2 ) significantly augmented IL-10 induced STAT3 and STAT1 phosphorylation, as well as suppressors of cytokine signaling 3 ( SOCS3 ) and IL-1R antagonist gene expression
Prêle et al., Immunology 2006 : SOCS3 over-expression had no effect on TNF-alpha mRNA levels induced by LPS or LPS plus IL-10 , or on IL-10 phosphorylation of STAT3, STAT1 and ERK1/2
Valencia-Pacheco et al., Scand J Rheumatol 2006 (Lupus Erythematosus, Systemic) : In addition, variable levels of Jak-1, Tyk-2, Stat-1 , and Stat-3 activation were induced by IL-10 in PBMCs from SLE patients and controls, with no significant differences in protein phosphorylation or kinetics of activation
Qin et al., J Immunol 2006 : IL-10 inhibits LPS induced IFN-beta gene expression and subsequent STAT-1alpha activation, but does not affect NF-kappaB activation
Flores et al., J Immunol 2007 : These data also demonstrated that the inhibitory effect of IFN-gamma on IL-10 expression was STAT-1 dependent and transcriptionally regulated
Kalliolias et al., J Immunol 2008 : IL-27 primed monocytes for augmented responses to TLR stimulation in a STAT1 dependent manner, altered IL-10 signaling, and attenuated IL-10 induced gene expression
Grundtner et al., Genes Immun 2009 (Colitis, Ulcerative...) : A reduction in IL-10 induced STAT1 and STAT3 activation was seen for IL-10R1-S138G ( but not IL-10R1-G330R ) by phosphospecific western blotting in both cell types ... In conclusion, the IL-10R1 S138G variant is a loss-of-function allele for IL-10 induced STAT1 and STAT3 activation but does not protect from UC susceptibility
Guarda et al., Immunity 2011 (Candidiasis...) : In addition, type I IFN induced IL-10 in a STAT1 dependent manner ; autocrine IL-10 then signaled via STAT3 to reduce the abundance of pro-IL-1a and pro-IL-1ß
Iwasaki et al., Eur J Immunol 2013 : Although IL-27 mediated IL-10 induction was dependent on both STAT1 and STAT3, only STAT3 was required for IL-27 mediated Egr-2 induction
Schulz et al., Blood 2013 (Leukemia, Lymphocytic, Chronic, B-Cell) : The increase in IL-10 levels lead to an induction of STAT1 phosphorylation in CLL cells and to enhanced cell-surface expression of intercellular adhesion molecule 1 and altered expression of cytoskeletal and migration related genes
Song et al., Blood 1997 : However, IL-10 did not affect IFN-gamma induced tyrosine phosphorylation of STAT-1alpha or alter STAT-1alpha binding to the IFN-gamma response element (IRE) in the ICAM-1 promoter
O'Farrell et al., EMBO J 1998 : In macrophages, IL-10 activates Stat1 and Stat3