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EGFR — GNRH1

Text-mined interactions from Literome

Roelle et al., J Biol Chem 2003 (MAP Kinase Signaling System) : Using a specific MMP2 and MMP9 inhibitor, Ro28-2653, GnRH dependent EGFR transactivation was abrogated ... Proving the specificity of the effect, transient transfection of alphaT3-1 cells with ribozymes directed against MMP2 or MMP9 specifically blocked EGFR tyrosine phosphorylation in response to GnRH stimulation
Shah et al., J Biol Chem 2004 : GnRH induced phosphorylation of the EGF-R and, subsequently, of Shc, ERK1/2, and its dependent protein, p90RSK-1 ( p90 ribosomal S6 kinase 1 or RSK-1 ), was abolished by metalloprotease inhibition
Shah et al., Trends Endocrinol Metab 2004 : Recent studies by Roelle et al. showed that GnRH induced activation of the EGF-R and extracellular signal regulated kinases 1 and 2 ( ERK1/2 ) in pituitary gonadotrophs occurs through ectodomain shedding of heparin binding-EGF (HB-EGF) by MMP2 and MMP9, indicating a crucial role for MMPs in GnRH signalling
Kraus et al., Cancer Res 2004 (MAP Kinase Signaling System...) : Indeed, in DU145 cells, GnRH-a activates the JNK cascade in a c-Src- and MLK3 dependent manner but does not involve protein kinase C and epidermal growth factor receptor