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EGFR — PLAU

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• STRING interaction: EGFR — PLAU (interaction, mapped from kegg_pathways)
• STRING interaction: PLAU — EGFR (interaction, mapped from grid reactome kegg_pathways)

Text-mined interactions from Literome

Wang et al., J Invest Dermatol 2005 (Carcinoma, Squamous Cell...) : As a result, uPA dependent focal adhesion kinase ( FAK ) and integrin mediated EGFR signaling are suppressed ... Both gangliosides inhibit uPAR signaling stimulated migration ; however, GM3 inhibits uPA induced EGFR phosphorylation by blocking the crosstalk between integrin and EGFR, whereas GT1b suppresses both uPA induced FAK and EGFR activation by preventing the activation of integrin alpha(5)beta ( 1 )
Nicholl et al., J Vasc Surg 2005 : Activation of the mitogen activated protein kinases ( MAPK ), extracellular signal regulated kinase 1/2 ( ERK1/2 ), p38 MAPK, Akt, MAP kinase/ERK kinase ( MEK1/2 ), MAP kinase kinase (MKK)3/6, and epidermal growth factor receptor (EGFR) in response to uPA was assayed by Western blot analysis for the phosphorylated form of each kinase ... uPA induced time dependent phosphorylation of EGFR , which was dependent on plasmin activity ... uPA activation of PI3K and MKK3/6 was EGFR dependent and that of MEK1 was EGFR independent
Gondi et al., Clin Cancer Res 2007 (Brain Neoplasms...) : In 4910 EGFR overexpressing cells, down-regulation of uPAR and uPA induced the down-regulation of EGFR and vascular endothelial growth factor and inhibited angiogenesis in both in vitro and in vivo angiogenic assays