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CX3CL1 — TNF

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: CX3CL1 → TNF (increases)
  Evidence: Fractalkine is the only chemokine in the category of CX3C chemokines (Bazan et al. 1997). It is a unique chemokine in that it not only acts as a chemoattractant, but also as an adhesion molecule that is expressed on endothelial cells upon stimulation with inflammatory molecules such as TNF-a , interferon g, and IL-1 (Bazan et al. 1997).

Text-mined interactions from Literome

Garcia et al., J Leukoc Biol 2000 : Fractalkine was induced in rat aortic endothelial cells ( RAEC ) by interleukin-1beta (IL-1beta), tumor necrosis factor alpha (TNF-alpha) , and lipopolysaccharide (LPS) transcriptionally and translationally
Matsumiya et al., Exp Cell Res 2001 (Inflammation) : sIL-6R markedly inhibited HUVEC fractalkine/CX3CL1 expression induced by interleukin (IL)-1alpha, tumor necrosis factor (TNF)-alpha , or interferon (IFN)-gamma
Ludwig et al., J Immunol 2002 : Fractalkine is expressed by smooth muscle cells in response to IFN-gamma and TNF-alpha and is modulated by metalloproteinase activity
Ollivier et al., Cytokine 2003 (Inflammation) : Here, we measured CX3CL1 mRNA and protein induction by human aortic smooth muscle cells ( SMCs ), another major component of vessel walls, in response to inflammatory stimuli, and analyzed the effect of membrane bound CX3CL1 on monocyte adhesion, tissue factor ( TF ) expression, and tumor necrosis factor-alpha (TNF-alpha) released
Mizuno et al., Brain Res 2003 : Fractalkine dose-dependently suppressed the production of nitric oxide ( NO ), interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha with activated microglia
Chen et al., Nephrol Dial Transplant 2003 (Glomerulonephritis) : Up-regulation of MC CX3CL1/fractalkine by TNF-alpha , IL-1beta, PDGF-AB and bFGF is mediated, at least in part, via the nuclear factor-kappaB signalling pathway
Park et al., Life Sci 2006 : The effects of AS-6 on TNF-alpha stimulated VCAM-1 and CX3CL1 expression were abolished in cells transfected with an adenovirus expressing dominant negative PPARgamma and in cells treated with a PPARgamma specific inhibitor, GW9662, confirming again that the anti-inflammatory effect of AS-6 was PPARgamma dependent
Bhavsar et al., FASEB J 2008 : We show, in lung A549 epithelial cells, that the tumor necrosis factor-alpha (TNF-alpha) and IFNgamma synergistically induced protein release and mRNA expression of CX(3)CL1 is inhibited by dexamethasone, without interfering with cytokine induced nuclear translocation of NF-kappaB, and by an inhibitor of IkappaB kinase 2, AS602868
Ishida et al., J Immunol 2008 (Disease Models, Animal...) : Furthermore, CX3CL1 enhanced the gene expression of IL-1beta, TNF-alpha , IFN-gamma, and IL-12 by WT macrophages with NF-kappaB activation
Matsumiya et al., J Immunol 2010 : Characterization of synergistic induction of CX3CL1/fractalkine by TNF-alpha and IFN-gamma in vascular endothelial cells : an essential role for TNF-alpha in post-transcriptional regulation of CX3CL1 ... CX3CL1/fractalkine , a chemokine specific to monocytes and NK cells, is induced synergistically by TNF-alpha and IFN-gamma in vascular endothelial cells ... CX3CL1 expression is under control of posttranscriptional regulation, which is involved in the synergistic induction of CX3CL1 in response to the combined stimulation with TNF-alpha and IFN-gamma
Isozaki et al., Journal of inflammation research 2008 : Synergistic induction of CX3CL1 by TNF alpha and IFN gamma in osteoblasts from rheumatoid arthritis : involvement of NF-kappa B and STAT-1 signaling pathways ... Although tumor necrosis factor (TNF)-a or interferon ( IFN ) -? alone RA OB induced negligible CX3CL1 secretion, the combination of TNF-a and IFN-? induced dramatic increases in both soluble CX3CL1 protein and mRNA transcripts
Rius et al., Arterioscler Thromb Vasc Biol 2013 (Atherosclerosis...) : The use of small interfering RNA revealed the involvement of tumor necrosis factor-a in Ang-II induced CX(3)CL1 upregulation and mononuclear cell arrest