◀ Back to LRPAP1

IL1A — LRPAP1

Text-mined interactions from Literome

Palsson et al., J Biol Chem 2000 : IL-1 also activated Rap in the cells, but with slower kinetics than Ras
McDermott et al., J Biol Chem 2002 : Interleukin-1 (IL-1) activates p38 MAP kinase via the small G protein Ras, and this activity can be down-regulated by another small G protein Rap ... Here we have further investigated the role of Ras and Rap in p38 MAPK activation by IL-1 ... In the same manner, the inhibitory effect of Rap on the activation of p38 by IL-1 occurred at a point downstream of MyD88, IRAK, and TRAF6, since the activation of p38 MAPK by these components was inhibited by overexpressing active Rap1AV12, while neither MKK3 nor MKK6 were affected