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IRS2 — SLC2A4
Text-mined interactions from Literome
Fasshauer et al., J Biol Chem 2000
:
Essential
role of
insulin receptor substrate-2 in insulin stimulation of
Glut4 translocation and glucose uptake in brown adipocytes
Zhou et al., J Biol Chem 1997
:
In the present study, we demonstrate that
IRS-2 can
mediate translocation of the insulin responsive glucose transporter
GLUT4 in a physiologically relevant target cell for insulin action ... To examine the
role of
IRS-2 in insulin stimulated translocation of
GLUT4 , we studied the effects of overexpression of IRS-1 and -2 on translocation of a co-transfected epitope tagged GLUT4 ( GLUT4-HA ) ... Overexpression of IRS-1 or
IRS-2 in adipose cells
resulted in a significant increase in the basal level of cell surface
GLUT4 ( in the absence of insulin )
Anai et al., Diabetes 1999
(Insulin Resistance) :
Insulin receptor substrate (IRS)-1 and
IRS-2 , which mediate phosphatidylinositol (PI) 3-kinase activation,
play essential roles in insulin induced translocation of
GLUT4 and in glycogen synthesis