Gene interactions and pathways from curated databases and text-mining

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CCNE2 — TP53

Text-mined interactions from Literome

Ariazi et al., Cancer Res 1999 (Mammary Neoplasms, Animal) : RNA expression studies, based on a multiplexed-nuclease protection assay, demonstrated that cell cycle- and apoptosis related genes were differentially expressed within 48 h of POH treatment ; p21 ( Cip1/WAF1 ), bax, bad, and annexin I were induced ; cyclin E and cyclin dependent kinase 2 were repressed ; and bcl-2 and p53 were unchanged
Suzuki et al., Int J Cancer 2000 (Mouth Neoplasms...) : TSA enhanced the protein expression of p21 ( WAF1 ), CREB binding protein, cyclinE , cyclin A, Bak and Bax, while it reduced the expression of E2F-1, E2F-4, HDAC1, p53 and hyperphosphorylated form of Rb
Sinicrope et al., Cancer prevention research (Philadelphia, Pa.) 2011 (Barrett Esophagus...) : Among the top 25 modulated genes, we found those regulating p53 mediated cell signaling ( RPL11 ), cell-cycle regulation ( cyclin E2 ), and cell adhesion and invasion ( Plexin1 )